4.6 Article

Genetic mechanisms underlying gray matter volume changes in patients with drug-naive first-episode schizophrenia

期刊

CEREBRAL CORTEX
卷 33, 期 5, 页码 2328-2341

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhac211

关键词

Allen Human Brain Atlas; drug-naive first-episode schizophrenia; genetic mechanisms; gray matter volume; meta-analysis

向作者/读者索取更多资源

Structural damage in the brain is a typical feature of schizophrenia. A neuroimaging meta-analysis of drug-naive first-episode schizophrenia patients revealed consistent reduction in gray matter volume (GMV) in the right superior temporal gyrus, right insula, and left inferior temporal gyrus. These GMV changes were found to be spatially associated with the expression levels of 1,201 genes, which exhibited diverse functional features.
Brain structural damage is a typical feature of schizophrenia. Investigating such disease phenotype in patients with drug-naive first-episode schizophrenia (DFSZ) may exclude the confounds of antipsychotics and illness chronicity. However, small sample sizes and marked clinical heterogeneity have precluded definitive identification of gray matter volume (GMV) changes in DFSZ as well as their underlying genetic mechanisms. Here, GMV changes in DFSZ were assessed using a neuroimaging meta-analysis of 19 original studies, including 605 patients and 637 controls. Gene expression data were derived from the Allen Human Brain Atlas and processed with a newly proposed standardized pipeline. Then, we used transcriptome-neuroimaging spatial correlations to identify genes associated with GMV changes in DFSZ, followed by a set of gene functional feature analyses. Meta-analysis revealed consistent GMV reduction in the right superior temporal gyrus, right insula and left inferior temporal gyrus in DFSZ. Moreover, we found that these GMV changes were spatially correlated with expression levels of 1,201 genes, which exhibited a wide range of functional features. Our findings may provide important insights into the genetic mechanisms underlying brain morphological abnormality in schizophrenia.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据