Hydroxycarbonate apatite formation and 5-fluorouracil delivery by strontium containing mesoporous bioactive glass nanoparticles

Sol-gel method was employed for the preparation of strontium-doped mesoporous bioactive glass nanoparticles (Sr-MBG NPs). These NPs have the size of 50 +/- 5 nm, a pore size of 8.2 nm, and a surface area of 379 m(2)/g. Biocompatibility was confirmed by MTT and tissue histopathology in Balb/c mice. 5-Fluorouracil (5-Fu) was loaded to obtain Fu-Sr-MBG NPs which posed substantial inhibitory effects on the viability of the cancer cells (AGS). The amount of released drug was controlled by changing the pH of release medium. Formation of hydroxycarbonate apatite (HCA) was evaluated in simulated body fluid (SBF) and confirmed by XRD and FTIR. Thus a multipurpose nano-biomaterial was prepared and screened.

Automated summary

Strontium-doped mesoporous bioactive glass nanoparticles (Sr-MBG NPs) with a size of 50 +/- 5 nm were successfully prepared using the sol-gel method. The biocompatibility of these nanoparticles was confirmed, and loading them with 5-fluorouracil (5-Fu) resulted in substantial inhibitory effects on cancer cell viability.