期刊
CERAMICS INTERNATIONAL
卷 48, 期 15, 页码 21378-21388出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2022.04.104
关键词
TiO2; Akermanite; 3D printing; Mechanical properties; Bone tissue applications
This report evaluated the mechanical behavior, bioactivity, and cytotoxicity of novel chitosan/akermanite-TiO2 (CS/AK/Ti) composite scaffolds fabricated using the 3D-printing method. It was found that the mechanical properties were significantly affected by the amount of TiO2, and the scaffolds possessed bone-like apatite forming ability with good cell behaviors. The outcomes suggested that the 3D-printed scaffolds have potential applications in bone tissue engineering.
This report aimed to evaluate the mechanical behavior, bioactivity, and cytotoxicity of novel chitosan/akermanite-TiO2 (CS/AK/Ti) composite scaffolds fabricated using the 3D-printing method. The morphological and structural properties of these scaffolds were characterized by Fourier transform spectroscopy (FTIR) and scanning electron microscopy (SEM). The mechanical behavior was examined by measuring the compressive strength, while the bioactivity was estimated in the simulated body fluid (SBF), and also the cytotoxicity of the scaffolds was assessed by conducting cell culturing experiments in vitro. It was found that the mechanical properties were considerably affected by the amount of TiO2. The scaffolds had the possessed bone-like apatite forming ability, which indicated high bioactivity. Furthermore, L929 cells spread well on the surface, proliferated, and had good viability regarding the cell behaviors. The outcomes confirmed that the morphological, biological, and mechanical properties of developed 3D-composite scaffolds nearly mimicked the features of natural bone tissue. In summary, these findings showed that the 3D-printed scaffolds with an interconnected pore structure and improved mechanical properties were a potential candidate for bone tissue applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据