期刊
CELL STEM CELL
卷 29, 期 5, 页码 678-691出版社
CELL PRESS
DOI: 10.1016/j.stem.2022.03.013
关键词
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资金
- National Science Foundation through the Center for Engineering MechanoBiology STC [CMMI: 15-48571]
- UPenn MRSEC program [DMR-1720530]
- National Institutes of Health [R01AR077362, R01AR056624, R01DE016523, R01DE120921, F31DK126427]
- German Science Foundation [QA 58/1-1]
- grant RECODE [2033723]
This article provides an overview of recent advances in the programming of synthetic hydrogels, which offer precise control over the spatiotemporal properties within cellular microenvironments. It highlights the importance of understanding complex biological processes.
The recapitulation of complex microenvironments that regulate cell behavior during development, disease, and wound healing is key to understanding fundamental biological processes. In vitro, multicellular morphogenesis, organoid maturation, and disease modeling have traditionally been studied using either non -physiological 2D substrates or 3D biological matrices, neither of which replicate the spatiotemporal biochemical and biophysical complexity of biology. Here, we provide a guided overview of the recent advances in the programming of synthetic hydrogels that offer precise control over the spatiotemporal properties within cellular microenvironments, such as advances in the control of cell-driven remodeling, bioprinting, or user-defined manipulation of properties (e.g., via light irradiation).
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