期刊
CELL METABOLISM
卷 34, 期 3, 页码 378-395出版社
CELL PRESS
DOI: 10.1016/j.cmet.2022.02.003
关键词
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资金
- European Research Council [802773-MitoGuide]
- SNSF [31003A_182470]
- Cancer Research Institute (Lloyd J. Old STAR award)
- Cancer Research Institute (CLIP Investigator award)
- EMBO Young Investigator award
- Melanoma Research Alliance Established Investigator Award
- Natural Science Foundation of China [NSFC 81971466]
- Institute of Systems Medicine, the Chinese Academy of Medical Sciences
This review summarizes recent advances in understanding the role of metabolism and epigenetics in determining the fate and function of T cells, and discusses strategies for improving T cell dysfunction through metabolic and epigenetic modulation.
Productive T cell responses to infection and cancer rely on coordinated metabolic reprogramming and epigenetic remodeling among the immune cells. In particular, T cell effector and memory differentiation, exhaustion, and senescence/aging are tightly regulated by the metabolism-epigenetics axis. In this re-view, we summarize recent advances of how metabolic circuits combined with epigenetic changes dictate T cell fate decisions and shape their functional states. We also discuss how the metabolic-epige-netic axis orchestrates T cell exhaustion and explore how physiological factors, such as diet, gut micro-biota, and the circadian clock, are integrated in shaping T cell epigenetic modifications and functionality. Furthermore, we summarize key features of the senescent/aged T cells and discuss how to ameliorate vaccination-and COVID-induced T cell dysfunctions by metabolic modulations. An in-depth understand-ing of the unexplored links between cellular metabolism and epigenetic modifications in various physio-logical or pathological contexts has the potential to uncover novel therapeutic strategies for fine-tuning T cell immunity.
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