期刊
CELL HOST & MICROBE
卷 30, 期 8, 页码 1093-+出版社
CELL PRESS
DOI: 10.1016/j.chom.2022.04.014
关键词
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资金
- National Cancer Institute of the NIH [U54CA260582]
- NIH [R01 HD095881, R01 AI150473]
- Glenn Barber Fellowship from the Ohio State University College of Veterinary Medicine
- Robert J. Anthony Fund for Cardiovascular Research
- JB Cardiovascular Research Fund
- National Center for Advancing Translational Sciences [UL1TR002733, KL2TR002734]
- Path to K Grant through the Ohio State University Center for Clinical & Translational Science
Recent reports show that SARS-CoV-2 Omicron variant sub-lineages BA.1, BA.1.1, and BA.2 have raised concerns about their ability to escape vaccine-induced and infection-induced immunity. A study finds that all Omicron sub-lineages, especially BA.1 and BA.1.1, exhibit significant immune escape, but this can be largely overcome by mRNA vaccine booster doses. The findings highlight the importance of booster vaccine doses for protection against all Omicron variants and provide insights into the immunity from natural infection against Omicron sub-lineages.
Recent reports of SARS-CoV-2 Omicron variant sub-lineages, BA.1, BA.1 .1 , and BA.2, have reignited concern over potential escape from vaccine- and infection-induced immunity. We examine the sensitivity of these sub-lineages and other major variants to neutralizing antibodies from mRNA-vaccinated and boosted individuals, as well as recovered COVID-19 patients, including those infected with Omicron. We find that all Omicron sub-lineages, especially BA.1 and BA.1.1, exhibit substantial immune escape that is largely overcome by mRNA vaccine booster doses. While Omicron BA.1.1 escapes almost completely from neutralization by early-pandemic COVID-1 9 patient sera and to a lesser extent from sera of Delta-infected patients, BA.1.1 is sensitive to Omicron-infected patient sera. Critically, all Omicron sub-lineages, including BA.2, are comparably neutralized by Omicron patient sera. These results highlight the importance of booster vaccine doses for protection against all Omicron variants and provide insight into the immunity from natural infection against Omicron sub-lineages.
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