QR code model: a new possibility for GPCR phosphorylation recognition

G protein-coupled receptors (GPCRs) are the largest family of membrane proteins in the human body and are responsible for accurately transmitting extracellular information to cells. Arrestin is an important member of the GPCR signaling pathway. The main function of arrestin is to assist receptor desensitization, endocytosis and signal transduction. In these processes, the recognition and binding of arrestin to phosphorylated GPCRs is fundamental. However, the mechanism by which arrestin recognizes phosphorylated GPCRs is not fully understood. The GPCR phosphorylation recognition bar code model and flute model describe the basic process of receptor phosphorylation recognition in terms of receptor phosphorylation sites, arrestin structural changes and downstream signaling. These two models suggest that GPCR phosphorylation recognition is a process involving multiple factors. This process can be described by a QR code model in which ligands, GPCRs, G protein-coupled receptor kinase, arrestin, and phosphorylation sites work together to determine the biological functions of phosphorylated receptors.

Automated summary

G protein-coupled receptors (GPCRs), with the assistance of arrestin, play a crucial role in receptor desensitization, endocytosis, and signal transduction. However, the mechanism by which arrestin recognizes phosphorylated GPCRs remains unclear. The GPCR phosphorylation recognition bar code model and flute model provide insights into the basic process of receptor phosphorylation recognition, involving multiple factors.