4.8 Article

The genomic origins of the world's first farmers

期刊

CELL
卷 185, 期 11, 页码 1842-+

出版社

CELL PRESS
DOI: 10.1016/j.cell.2022.04.008

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资金

  1. Swiss NSF [310030_200420, 310030_188883, 31003A_173062]
  2. German Science Foundation [BU 1403/6-1]
  3. Humboldt foundation
  4. Greek-German bilateral agreement (GSRT) project BIOMUSE [5030121]
  5. Greek-German bilateral agreement (BMBF) project BIOMUSE [5030121]
  6. Serbian Ministry of Science project [III47001]
  7. Czech Grant Agency-GACR [21-17092X]
  8. National Institutes of Health [R01GM127348]
  9. ERC BIRTH project [640557]
  10. European Research Council under the European Union's Horizon 2020 research and innovation program-ERC-2019-SyG [856453]
  11. Marie Sk1odowskaCurie actions ITN BEAN
  12. Marie Sk1odowska-Curie individual fellowship [793893]
  13. EMBO Long-Term Fellowship [ALTF 445-2017]
  14. Seal of Excellence Fund grant from the University of Berne [SELF2018-04]
  15. Mainz University
  16. Swiss National Science Foundation (SNF) [310030_200420, 31003A_173062, 310030_188883] Funding Source: Swiss National Science Foundation (SNF)
  17. Marie Curie Actions (MSCA) [793893] Funding Source: Marie Curie Actions (MSCA)
  18. European Research Council (ERC) [640557, 856453] Funding Source: European Research Council (ERC)

向作者/读者索取更多资源

Demogenomic modeling of ancient genomes sheds light on the genetic origins and differentiation process of early farming populations in Europe and Southwest Asia, as well as the genetic drift they experienced during their migration.
The precise genetic origins of the first Neolithic farming populations in Europe and Southwest Asia, as well as the processes and the timing of their differentiation, remain largely unknown. Demogenomic modeling of high-quality ancient genomes reveals that the early farmers of Anatolia and Europe emerged from a multi-phase mixing of a Southwest Asian population with a strongly bottlenecked western hunter-gatherer population after the last glacial maximum. Moreover, the ancestors of the first farmers of Europe and Anatolia went through a period of extreme genetic drift during their westward range expansion, contributing highly to their genetic distinctiveness. This modeling elucidates the demographic processes at the root of the Neolithic transition and leads to a spatial interpretation of the population history of Southwest Asia and Europe during the late Pleistocene and early Holocene.

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