期刊
CARBON
卷 190, 期 -, 页码 194-244出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.carbon.2021.12.084
关键词
Nanomaterials; Biomedical applications; Photodynamic therapy; Photothermal therapy; Combined phototherapy
资金
- Laboratory for Process Engineering, Environment, Biotechnology and Energy e LEPABE - national funds through the FCT/MCTES (PIDDAC) [UIDB/00511/2020, UIDP/00511/2020]
- Institute for Research and Innovation in Health - i3S [UIDB/04293/2020]
- FEDER
- FCT/MCTES [POCI-01-0145-FEDER-031143, PTDC/BTM-MAT/31143/2017]
- Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) [NORTE-01-0145-FEDER-000054]
- Portuguese Foundation for Science and Technology (FCT) [CEECIND/03908/2017]
- Fundação para a Ciência e a Tecnologia [PTDC/BTM-MAT/31143/2017] Funding Source: FCT
This review provides a comprehensive overview and integrative approach to carbon nanomaterials (CNM) colloids as multifunctional agents in phototherapy. It focuses on their applications in cancer and antimicrobial treatments, covering material structures and properties, surface modification strategies, therapy modalities, safety concerns, and potential developments.
Carbon nanomaterials (CNM) have gained great interest in the scientific community and motivated multiple studies in the biomedical field thanks to their unique properties. The present review intends to provide not only a comprehensive overview but also an integrative approach of the state-of-the-art knowledge on CNM colloids as multifunctional agents in phototherapy (photodynamic and photo thermal therapy), focusing on cancer and antimicrobial applications. Firstly, an overview of the structures and properties of each material and of the numerous surface modification strategies employed to enhance their effectiveness will be presented. Then, the most relevant studies developed for each different type of therapy modality will be highlighted, as well as the experimental conditions used to achieve an effective anticancer or antimicrobial effect in vitro and in vivo. Focus is also placed on identifying the mechanisms for each CNM and CNM-conjugates that lead to effective photothermal or photodynamic therapy, with the simultaneous use of both being considered as well. Finally, key safety and biocompatibility concerns regarding CNM use will be presented, and new potential developments and prospective challenges in the field discussed. (c) 2022 Elsevier Ltd. All rights reserved.
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