期刊
CARBOHYDRATE POLYMERS
卷 281, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.119080
关键词
Chitosan; Lignosulfonate; Polyelectrolyte composite micelles; Curcumin; Delivery system
资金
- Science and Technology Project of Department of Science and Technology of Sichuan Province: Key research and development projects [22ZDYF0157]
Chitosan/lignosulfonate composite micelles were successfully prepared and used to encapsulate curcumin. The encapsulation improved the stability, retention efficiency, and antioxidant activity of curcumin. These findings support the potential use of CS-LS as a delivery system for encapsulating hydrophobic biologically active substances.
In this work, chitosan/lignosulfonate composite micelles (CS-LS) were successfully prepared through polyelectrolyte self-assembly. Curcumin was encapsulated in CS-LS to obtain CUR-CS-LS. The results showed that the average diameter of CS-LS and CUR-CS-LS were 239 nm and 286 nm, respectively. The results show that the aromatic rings of lignosulfonate are assembled into the hydrophobic core of micelles through pi-pi interactions, and chitosan binds outside the hydrophobic core as a hydrophilic shell through electrostatic interactions. Curcumin is encapsulated in the hydrophobic core through hydrophobic interactions. Encapsulation improves the thermal stability and pH stability of curcumin. Compared with free curcumin, the retention efficiency of curcumin in CUR-CS-LS increased by approximately 6.66 and 6.46 times under the same heat treatment and pH conditions, respectively. Encapsulation also increases the antioxidant activity of curcumin in aqueous solution. In addition, the release mechanism of curcumin is diffusion and matrix swelling. These findings explain that CS-LS may be an effective promising delivery system for encapsulating hydrophobic biologically active substances.
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