期刊
CARBOHYDRATE POLYMERS
卷 285, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119223
关键词
Bi-layered carboxymethyl cellulose-collagen; vitrigel membrane; Cell -adhesion inhibition; Wound regeneration; Adhesion-inhibitor; Collagen hydrogel; Anti-adhesion membrane
资金
- JSPS KAKENHI [23680055, 18K14061, 20K05227]
- Toyoaki Scholarship Foundation
- Tatematsu Foundation
- Grants-in-Aid for Scientific Research [23680055, 18K14061, 20K05227] Funding Source: KAKEN
During wound regeneration, a membrane with dual surfaces, combining the properties of carboxymethyl cellulose (CMC) and collagen, was developed using vitrification. This membrane provides strong cell adhesion-inhibition and cell adhesion simultaneously.
During wound regeneration, both cell adhesion and adhesion-inhibitory functions must be controlled in parallel. We developed a membrane with dual surfaces by merging the properties of carboxymethyl cellulose (CMC) and collagen using vitrification. A rigid membrane was formed by vitrification of a bi-layered CMC and collagen hydrogel without using cross-linking reagents, thus providing dual functions, strong cell adhesion-inhibition with the CMC layer, and cell adhesion with the collagen layer. We referred to this bi-layered CMC-collagen vitrigel membrane as Bi-C-CVM and optimized the process and materials. The introduction of the CMC layer conferred a tough but stably wet property to Bi-C-CVM. This enables Bi-C-CVM to cover wet tissue and make the membrane non-detachable while preventing tissue adhesion on the other side. The bi-layered vitrification procedure can expand the customizability of collagen vitrigel devices for wider medical applications.
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