The isolation, structural features and biological activities of polysaccharide from Ligusticum chuanxiong: A review

Ligusticum chuanxiong, the dried rhizome of Ligusticum chuanxiong Hort, has been widely applied in traditional Chinese medicine for treating plague, and it has appeared frequently in the prescriptions against COVID-19 lately. Ligusticum chuanxiong polysaccharide (LCPs) is one of the effective substances, which has various activities, such as, anti-oxidation, promoting immunity, anti-tumor, and anti-bacteria. The purified fractions of LCPs are considered to be pectic polysaccharides, which are mainly composed of GalA, Gal, Ara and Rha, and are generally linked by alpha-1,4-D-GalpA, alpha-1,2-L-Rhap, alpha-1,5-L-Araf, beta-1,3-D-Galp and beta-1,4-D-Galp, etc. The pectic polysaccharide shows an anti-infective inflammatory activity, which is related to antiviral infection of Ligusticum chuanxiong. In this article, the isolation, purification, structural features, and biological activities of LCPs in recent years are reviewed, and the potential of LCPs against viral infection as well as questions that need future research are discussed.

Automated summary

Ligusticum chuanxiong, a widely used medicinal herb in traditional Chinese medicine for treating plague, has recently been incorporated into prescriptions against COVID-19. Ligusticum chuanxiong polysaccharide (LCPs) is an effective substance with various activities including anti-oxidation, immune modulation, anti-tumor, and anti-bacterial effects. This article provides a review of the isolation, purification, structural features, and biological activities of LCPs in recent years, as well as discusses the potential of LCPs against viral infections and areas for future research.