4.8 Article

Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Chemistry, Physical

Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases

Masayuki Fujii et al.

Summary: This review highlights the approaches used to generate somatic cell-derived organoids for modeling epithelial tissue and understanding disease progression. It discusses how advancements in understanding the regulation of epithelial tissue stem cells have led to the development of organoids, which retain the characteristics of their tissue of origin. Additionally, it mentions the growing effort in using organoids to model human diseases and their contributions to understanding disease biology.

NATURE MATERIALS (2021)

Article Oncology

An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence

Eugen Dhimolea et al.

Summary: Our study reveals that treatment-persistent tumor cells in cancer patients adopt a reversible transcriptional program similar to embryonic diapause, which allows them to resist chemotherapy-induced cytotoxicity. Inhibiting Myc activity or interfering with the diapause-like adaptation could be potential therapeutic strategies against chemotherapy-persistent tumor cells.

CANCER CELL (2021)

Article Biochemistry & Molecular Biology

Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

Sumaiyah K. Rehman et al.

Summary: It has been discovered that cancer cells enter a drug-tolerant persister state to evade treatment, showing similarities with diapause in embryonic development. All cancer cells possess the potential to become drug-tolerant persisters, rather than just a small subpopulation.
Article Ecology

Selection of metastasis competent subclones in the tumour interior

Yue Zhao et al.

Summary: The study combines whole-tumour images and genomic data to reveal more aggressive subclonal growth and metastasizing subclones in the tumor center. Spatial dynamics strongly correlate with genomic alterations and play a significant role in tumor evolution.

NATURE ECOLOGY & EVOLUTION (2021)

Article Oncology

Modeling Breast Cancer Using CRISPR-Cas9-Mediated Engineering of Human Breast Organoids

Johanna F. Dekkers et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2020)

Article Biochemistry & Molecular Biology

Stable expansion of high-grade serous ovarian cancer organoids requires a low-Wnt environment

Karen Hoffmann et al.

EMBO JOURNAL (2020)

Article Multidisciplinary Sciences

Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages

Jennifer M. Rosenbluth et al.

NATURE COMMUNICATIONS (2020)

Article Medicine, Research & Experimental

FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease

Susana Garcia-Recio et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Multidisciplinary Sciences

MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression

Kung-Chi Chang et al.

NATURE COMMUNICATIONS (2020)

Review Public, Environmental & Occupational Health

Racial Disparities in Triple Negative Breast Cancer: A Review of the Role of Biologic and Non-biologic Factors

Om Prakash et al.

FRONTIERS IN PUBLIC HEALTH (2020)

Article Multidisciplinary Sciences

Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups

Oscar M. Rueda et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

Oded Kopper et al.

NATURE MEDICINE (2019)

Article Biochemistry & Molecular Biology

Comprehensive Integration of Single-Cell Data

Tim Stuart et al.

Review Multidisciplinary Sciences

Cancer modeling meets human organoid technology

David Tuveson et al.

SCIENCE (2019)

Article Multidisciplinary Sciences

Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis

Ines Godet et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

COSMIC: the Catalogue Of Somatic Mutations In Cancer

John G. Tate et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biotechnology & Applied Microbiology

Vireo: Bayesian demultiplexing of pooled single-cell RNA-seq data without genotype reference

Yuanhua Huang et al.

GENOME BIOLOGY (2019)

Article Biochemistry & Molecular Biology

ClinVar: improving access to variant interpretations and supporting evidence

Melissa J. Landrum et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

Norman Sachs et al.

Article Biotechnology & Applied Microbiology

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Andrew Butler et al.

NATURE BIOTECHNOLOGY (2018)

Editorial Material Cell Biology

Mammary lineage restriction in development

Philip Bland et al.

NATURE CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity

Quy H. Nguyen et al.

NATURE COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

Maftools: efficient and comprehensive analysis of somatic variants in cancer

Anand Mayakonda et al.

GENOME RESEARCH (2018)

Article Genetics & Heredity

REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants

Nilah M. Ioannidis et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2016)

Article Biochemistry & Molecular Biology

SMASH, a fragmentation and sequencing method for genomic copy number analysis

Zihua Wang et al.

GENOME RESEARCH (2016)

Article Multidisciplinary Sciences

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Serena Nik-Zainal et al.

NATURE (2016)

Article Biotechnology & Applied Microbiology

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

Channing Yu et al.

NATURE BIOTECHNOLOGY (2016)

Article Biochemistry & Molecular Biology

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

Sylvia F. Boj et al.

Article Biochemistry & Molecular Biology

Luminal Progenitors Restrict Their Lineage Potential during Mammary Gland Development

Veronica Rodilla et al.

PLOS BIOLOGY (2015)

Article Oncology

US Incidence of Breast Cancer Subtypes Defined by Joint Hormone Receptor and HER2 Status

Nadia Howlader et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2014)

Article Genetics & Heredity

Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins

Yongxing Gong et al.

NATURE GENETICS (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Article Biochemistry & Molecular Biology

VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing

Daniel C. Koboldt et al.

GENOME RESEARCH (2012)

Article Multidisciplinary Sciences

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

Sohrab P. Shah et al.

NATURE (2012)

Article Multidisciplinary Sciences

Systematic identification of genomic markers of drug sensitivity in cancer cells

Mathew J. Garnett et al.

NATURE (2012)

Article Multidisciplinary Sciences

Comprehensive molecular portraits of human breast tumours

Daniel C. Koboldt et al.

NATURE (2012)

Article Multidisciplinary Sciences

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

Christina Curtis et al.

NATURE (2012)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Article Biochemical Research Methods

BamTools: a C++ API and toolkit for analyzing and managing BAM files

Derek W. Barnett et al.

BIOINFORMATICS (2011)

Article Medicine, Research & Experimental

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

Brian D. Lehmann et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Review Oncology

Deconstructing the molecular portraits of breast cancer

Aleix Prat et al.

MOLECULAR ONCOLOGY (2011)

Letter Biotechnology & Applied Microbiology

Integrative genomics viewer

James T. Robinson et al.

NATURE BIOTECHNOLOGY (2011)

Article Oncology

Molecular Stratification of Triple-Negative Breast Cancers

Charles M. Perou

ONCOLOGIST (2011)

Article Biochemistry & Molecular Biology

Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates

Oe Yalcin-Ozuysal et al.

CELL DEATH AND DIFFERENTIATION (2010)

Article Biochemistry & Molecular Biology

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

Kai Wang et al.

NUCLEIC ACIDS RESEARCH (2010)

Article Biochemical Research Methods

The Sequence Alignment/Map format and SAMtools

Heng Li et al.

BIOINFORMATICS (2009)

Article Biochemical Research Methods

Fast and accurate short read alignment with Burrows-Wheeler transform

Heng Li et al.

BIOINFORMATICS (2009)

Article Medicine, General & Internal

A compact VEGF signature associated with distant metastases and poor outcomes

Zhiyuan Hu et al.

BMC MEDICINE (2009)

Article Oncology

Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes

Joel S. Parker et al.

JOURNAL OF CLINICAL ONCOLOGY (2009)

Article Cell & Tissue Engineering

Transcriptome analysis of the normal human mammary cell commitment and differentiation process

Afshin Raouf et al.

CELL STEM CELL (2008)

Article Cell & Tissue Engineering

Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment

Toula Bouras et al.

CELL STEM CELL (2008)

Article Biotechnology & Applied Microbiology

Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors

Jason I. Herschkowitz et al.

GENOME BIOLOGY (2007)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Repeated observation of breast tumor subtypes in independent gene expression data sets

T Sorlie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Multidisciplinary Sciences

Molecular portraits of human breast tumours

CM Perou et al.

NATURE (2000)