期刊
CANCER LETTERS
卷 531, 期 -, 页码 1-13出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2022.01.031
关键词
Long noncoding RNA; Non-small cell lung cancer; Tumor suppressor gene; Metastasis; Thioredoxin interacting protein
类别
资金
- National Natural Science Foundation of China [82103248, 81402278, 81772461, 81972208]
- National Key Research and Development Program of China [2018YFC1313604]
- Chinese Society of Clinical Oncology (CSCO) [Y-2019AZZD-0038]
- Shanghai Natural Science Foundation of China [19ZR1452700]
The study found that LHFPL3-AS2 is a novel long noncoding RNA that is significantly decreased in non-small cell lung cancer (NSCLC) tissues. Low levels of LHFPL3-AS2 expression were highly correlated with poor overall survival, TNM stage, and metastasis of NSCLC patients. Enhanced expression of LHFPL3-AS2 inhibited NSCLC invasion and metastasis.
Lung cancer is the most common cancer and the leading cause of cancer deaths worldwide. In addition to coding genes, the contribution of long noncoding RNA (lncRNA) to non-small cell lung cancer (NSCLC) remains unclear. Here, we explored lncRNA expression profiles by Affymetrix Gene Chip Human Transcriptome Array 2.0 in 37 paired samples of tumorous NSCLC tissues and adjacent nontumorous tissues. We showed that LHFPL3-AS2 is a novel lncRNA, significantly decreased in NSCLC tissues. LHFPL3-AS2 was further validated in an additional 93 paired samples of NSCLC. Low levels of LHFPL3-AS2 expression were highly correlated with poor overall survival, TNM stage, and metastasis of NSCLC patients. Enhanced expression of LHFPL3-AS2 inhibited NSCLC invasion and metastasis in vitro and in vivo. Moreover, downregulation of LHFPL3-AS2 reduced its specific interaction with SFPQ, resulting in more SFPQ binding to the promoter of TXNIP and causing the transcriptional repression of TXNIP, thus finally promoting the migration and invasion of NSCLC cells. Furthermore, LHFPL3AS2 was shown to be regulated by EGR1 under hypoxia.
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