4.7 Article

Chimeric antigen receptor clustering via cysteines enhances T-cell efficacy against tumor

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells

Nathan Singh et al.

Summary: The study found CD22 to be an alternative immunotherapy target in ALL, with the pilot clinical trials of 4-1BB-based CAR T cells targeting CD22 showing unexpectedly low response rates. It highlights the beneficial role of autonomous signaling in CAR function and demonstrates the utility of bedside-to-bench-to-bedside translation in designing and implementing CAR T cell therapies.

NATURE MEDICINE (2021)

Review Immunology

Optimization of T Cell Redirecting Strategies: Obtaining Inspirations From Natural Process of T Cell Activation

Yiyuan Gao et al.

Summary: Using CARs or bsAbs to redirect T cells against tumors is a promising immunotherapy approach, but clinical outcomes remain insufficient. Limited efficacy and poor persistence are major challenges in T cell therapies. Understanding the structure and signaling characteristics of the immunological synapse (IS) formed by natural and redirected T cells can provide potential strategies to enhance efficacy and persistence.

FRONTIERS IN IMMUNOLOGY (2021)

Article Biochemical Research Methods

Tumor organoid-T-cell coculture systems

Chiara M. Cattaneo et al.

NATURE PROTOCOLS (2020)

Review Immunology

Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells

Ling Wu et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

Clustering of the ζ-Chain Can Initiate T Cell Receptor Signaling

Yuanqing Ma et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Oncology

Tuning the Antigen Density Requirement for CAR T-cell Activity

Robbie G. Majzner et al.

CANCER DISCOVERY (2020)

Review Oncology

Engineering CAR-T Cells for Next-Generation Cancer Therapy

Mihe Hong et al.

CANCER CELL (2020)

Article Immunology

Inefficient CAR-proximal signaling blunts antigen sensitivity

Venugopal Gudipati et al.

NATURE IMMUNOLOGY (2020)

Review Chemistry, Multidisciplinary

The CAR T-Cell Mechanoimmunology at a Glance

Rui Li et al.

ADVANCED SCIENCE (2020)

Review Cell Biology

How does T cell receptor clustering impact on signal transduction?

Jesse Goyette et al.

JOURNAL OF CELL SCIENCE (2019)

Review Biochemistry & Molecular Biology

Clinical lessons learned from the first leg of the CAR T cell journey

Robbie G. Majzner et al.

NATURE MEDICINE (2019)

Article Biochemistry & Molecular Biology

Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling

Aruna Bitra et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Review Oncology

Chimeric antigen receptor T-cell therapies for lymphoma

Jennifer N. Brudno et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Review Medicine, General & Internal

Chimeric Antigen Receptor Therapy

Carl H. June et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Multidisciplinary Sciences

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

A. J. Davenport et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Chemistry, Multidisciplinary

Chemistry and Enzymology of Disulfide Cross-Linking in Proteins

Deborah Fass et al.

CHEMICAL REVIEWS (2018)

Article Biochemistry & Molecular Biology

Human primary liver cancer-derived organoid cultures for disease modeling and drug screening

Laura Broutier et al.

NATURE MEDICINE (2017)

Article Multidisciplinary Sciences

An intermolecular FRET sensor detects the dynamics of T cell receptor clustering

Yuanqing Ma et al.

NATURE COMMUNICATIONS (2017)

Article Biology

IgY: a key isotype in antibody evolution

Xiaoying Zhang et al.

BIOLOGICAL REVIEWS (2017)

Article Biochemistry & Molecular Biology

A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination

Marcus J. Taylor et al.

Review Medicine, Research & Experimental

CAR-T Cell Therapy for Lymphoma

Carlos A. Ramos et al.

ANNUAL REVIEW OF MEDICINE, VOL 67 (2016)

Review Oncology

Driving CAR T-cells forward

Hollie J. Jackson et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2016)

Article Multidisciplinary Sciences

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

Sophie V. Pageon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Oncology

Fine-tuning the CAR spacer improves T-cell potency

Norihiro Watanabe et al.

ONCOIMMUNOLOGY (2016)

Article Biochemistry & Molecular Biology

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

Adrienne H. Long et al.

NATURE MEDICINE (2015)

Review Immunology

Engineering CAR-T cells: Design concepts

Shivani Srivastava et al.

TRENDS IN IMMUNOLOGY (2015)

Review Oncology

The Basic Principles of Chimeric Antigen Receptor Design

Michel Sadelain et al.

CANCER DISCOVERY (2013)

Review Immunology

Immunological synapse and microclusters: the site for recognition and activation of T cells

Takashi Saito et al.

CURRENT OPINION IN IMMUNOLOGY (2006)