4.6 Review

Review of bi-specific therapies in uveal melanoma

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Review Oncology

How to Make Immunotherapy an Effective Therapeutic Choice for Uveal Melanoma

Mariarosaria Marseglia et al.

Summary: Despite improvements in early identification and control of primary uveal melanoma, 50% of patients develop metastatic disease with little efficacy from targeted therapies. Immunotherapy, although effective in cutaneous melanoma, shows limited results in treating uveal melanoma due to its unique tumor microenvironment and immune responses.

CANCERS (2021)

Meeting Abstract Oncology

Overall survival benefit from tebentafusp in patients with best response of progressive disease.

Anthony M. Joshua et al.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Medicine, General & Internal

Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma

Paul Nathan et al.

Summary: The randomized trial of tebentafusp for metastatic uveal melanoma showed a higher 1-year overall survival rate among patients who received tebentafusp compared to those who received the investigator's choice of therapy, indicating superior efficacy.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Biochemistry & Molecular Biology

The Role of Immune Checkpoint Blockade in Uveal Melanoma

Anja Wessely et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Single-cell analysis reveals new evolutionary complexity in uveal melanoma

Michael A. Durante et al.

NATURE COMMUNICATIONS (2020)

Review Oncology

Treatment of Metastatic Uveal Melanoma: Systematic Review

Cristina Rodriguez-Vidal et al.

CANCERS (2020)

Meeting Abstract Oncology

Resensitization of uveal melanoma (UM) to immune checkpoint inhibition (ICI) by IMCgp100 (IMC).

Jessica Yang et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

Meeting Abstract Oncology

Phase II study of ipilimumab and nivolumab (ipi/nivo) in metastatic uveal melanoma (UM).

Meredith Pelster et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

Review Oncology

Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types

Monique K. van der Kooij et al.

CANCERS (2019)

Article Medicine, Research & Experimental

PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers

Mark Yarchoan et al.

JCI INSIGHT (2019)

Review Pharmacology & Pharmacy

Bispecific antibodies for cancer therapy: A review

Anuradha Krishnamurthy et al.

PHARMACOLOGY & THERAPEUTICS (2018)

Article Medicine, General & Internal

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

J. Larkin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Biochemistry & Molecular Biology

Metastasis with a little help from MDSCs

Victoria Aranda

NATURE MEDICINE (2011)