4.7 Review

MUC1 is a potential target to overcome trastuzumab resistance in breast cancer therapy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

A phase II randomised study of preoperative trastuzumab alone or combined with everolimus in patients with early HER2-positive breast cancer and predictive biomarkers (RADHER trial)

Mario Campone et al.

Summary: Adding everolimus to preoperative trastuzumab did not improve efficacy but induced MAPK signaling in HER2-positive early operable breast cancer patients. Combination therapy should be considered to maximize the effectiveness of trastuzumab in this setting.

EUROPEAN JOURNAL OF CANCER (2021)

Review Oncology

Crosstalk between MUC1 and VEGF in angiogenesis and metastasis: a review highlighting roles of the MUC1 with an emphasis on metastatic and angiogenic signaling

Farnaz Khodabakhsh et al.

Summary: VEGF and its receptor family play significant roles in pathological processes such as angiogenesis in tumor growth and metastasis. Overexpression of MUC1 on tumor cells leads to upregulation of various signaling pathways related to growth and survival.

CANCER CELL INTERNATIONAL (2021)

Article Oncology

Phase 1 study of M2698, a p70S6K/AKT dual inhibitor, in patients with advanced cancer

Apostolia-Maria Tsimberidou et al.

Summary: The study demonstrated that M2698 has anti-tumor activity in patients with advanced breast cancer, with good tolerability, making it a candidate for further research.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Article Oncology

The Novel Oral mTORC1/2 Inhibitor TAK-228 Reverses Trastuzumab Resistance in HER2-Positive Breast Cancer Models

Marta Sanz-Alvarez et al.

Summary: Hyperactivation of the PI3K/AKT/mTOR pathway is a known mechanism of trastuzumab resistance in HER2-positive breast cancer. The use of mTOR inhibitor TAK-228 can reverse this resistance and enhance response to trastuzumab. Therefore, combining trastuzumab with PI3K/AKT/mTOR inhibitors may be a potential strategy for inhibiting proliferation in HER2-positive breast cancer cells with resistance to trastuzumab.

CANCERS (2021)

Article Pharmacology & Pharmacy

Development, Characterization, and In Vivo Evaluation of a Novel Aptamer (Anti-MUC1/Y) for Breast Cancer Therapy

Huma Khan et al.

Summary: MUC1/Y, a transmembrane glycoprotein overexpressed in epithelial cancers, lacks the variable repeat region and plays a role in oncogenic processes; A DNA aptamer specifically targeting MUC1/Y was developed and shown to inhibit tumor growth both in vitro and in vivo, highlighting the potential of DNA aptamers as a new therapeutic tool for cancer treatment.

PHARMACEUTICS (2021)

Review Cell Biology

Role of STAT3 signaling pathway in breast cancer

Jia-hui Ma et al.

CELL COMMUNICATION AND SIGNALING (2020)

Article Biochemistry & Molecular Biology

Novel Antibodies Targeting MUC1-C Showed Anti-Metastasis and Growth-Inhibitory Effects on Human Breast Cancer Cells

Min Jung Kim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Oncology

Signal Transduction Pathways in Breast Cancer: The Important Role of PI3K/Akt/mTOR

Miguel A. Ortega et al.

JOURNAL OF ONCOLOGY (2020)

Article Pharmacology & Pharmacy

Dual inhibition of STAT1 and STAT3 activation downregulates expression of PD-L1 in human breast cancer cells

Varun Sasidharan Nair et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2018)

Review Biochemistry & Molecular Biology

The Multifaceted Role of STAT3 in Mammary Gland Involution and Breast Cancer

Katherine Hughes et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Pharmacology & Pharmacy

Monoclonal antibody-based therapeutics, targeting the epidermal growth factor receptor family: from herceptin to Pan HER

Shima Moradi-Kalbolandi et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2018)

Article Biochemistry & Molecular Biology

Targeting MUC1-C suppresses BCL2A1 in triple-negative breast cancer

Masayuki Hiraki et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2018)

Article Oncology

MUC1-C Induces PD-L1 and Immune Evasion in Triple-Negative Breast Cancer

Takahiro Maeda et al.

CANCER RESEARCH (2018)

Review Oncology

MUC1 induces tamoxifen resistance in estrogen receptor-positive breast cancer

Parnaz Merikhian et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2017)

Article Oncology

Multifunctional receptor-targeting antibodies for cancer therapy

Yanni Zhu et al.

LANCET ONCOLOGY (2015)

Review Biochemistry & Molecular Biology

Mechanisms of action of therapeutic antibodies for cancer

J. M. Redman et al.

MOLECULAR IMMUNOLOGY (2015)

Editorial Material Medicine, General & Internal

The Path to Cancer - Three Strikes and You're Out

Bert Vogelstein et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Review Oncology

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

Mark A. Feitelson et al.

SEMINARS IN CANCER BIOLOGY (2015)

Article Multidisciplinary Sciences

Characterization of the MUC1-C Cytoplasmic Domain as a Cancer Target

Deepak Raina et al.

PLOS ONE (2015)

Review Biochemistry & Molecular Biology

Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors

Kodappully Sivaraman Siveen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2014)

Review Oncology

Trastuzumab emtansine: mechanisms of action and drug resistance

Mark Barok et al.

BREAST CANCER RESEARCH (2014)

Review Oncology

Targeting the PI3K/AKT/mTOR pathway in estrogen receptor-positive breast cancer

Eva Maria Ciruelos Gil

CANCER TREATMENT REVIEWS (2014)

Review Immunology

Breast cancer immunotherapy: monoclonal antibodies and peptide-based vaccines

Elham Mohit et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2014)

Article Biochemistry & Molecular Biology

An Investigation of the Effects of the Core Protein Telomerase Reverse Transcriptase on Wnt Signaling in Breast Cancer Cells

Imke Listerman et al.

MOLECULAR AND CELLULAR BIOLOGY (2014)

Review Biotechnology & Applied Microbiology

PI3K and cancer: lessons, challenges and opportunities

David A. Fruman et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Oncology

Effect of MUC1 siRNA on Drug Resistance of Gastric Cancer Cells to Trastuzumab

Min Deng et al.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2013)

Article Pharmacology & Pharmacy

Molecular aspects of cancer cell resistance to chemotherapy

Magali Rebucci et al.

BIOCHEMICAL PHARMACOLOGY (2013)

Article Biochemistry & Molecular Biology

MUC1-C Oncoprotein Activates ERK→C/EBPβ Signaling and Induction of Aldehyde Dehydrogenase 1A1 in Breast Cancer Cells

Maroof Alam et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Oncology

Oncogenic MUC1-C Promotes Tamoxifen Resistance in Human Breast Cancer

Akriti Kharbanda et al.

MOLECULAR CANCER RESEARCH (2013)

Review Multidisciplinary Sciences

Antibody Therapeutics in Cancer

Mark X. Sliwkowski et al.

SCIENCE (2013)

Review Biotechnology & Applied Microbiology

Role of STAT3 in Cancer Metastasis and Translational Advances

Mohammad Zahid Kamran et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Article Oncology

Therapeutic strategies and mechanisms of tumorigenesis of HER2-overexpressing breast cancer

Anna Emde et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2012)

Article Biochemistry & Molecular Biology

The MUC1-C Oncoprotein Binds to the BH3 Domain of the Pro-apoptotic BAX Protein and Blocks BAX Function

Rehan Ahmad et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Oncology

MUC1 Drives c-Met-Dependent Migration and Scattering

Teresa M. Horm et al.

MOLECULAR CANCER RESEARCH (2012)

Review Oncology

Treatment of HER2-positive breast cancer: current status and future perspectives

Carlos L. Arteaga et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2012)

Article Medicine, General & Internal

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

Sunil Verma et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Endocrinology & Metabolism

MUC1-C oncoprotein confers androgen-independent growth of human prostate cancer cells

Hasan Rajabi et al.

PROSTATE (2012)

Review Oncology

Mechanisms of Resistance to Trastuzumab and Novel Therapeutic Strategies in HER2-Positive Breast Cancer

Andrea L. A. Wong et al.

INTERNATIONAL JOURNAL OF BREAST CANCER (2012)

Article Oncology

The ERBB network: at last, cancer therapy meets systems biology

Yosef Yarden et al.

NATURE REVIEWS CANCER (2012)

Review Medicine, Research & Experimental

Mechanisms of Endocrine Resistance in Breast Cancer

C. Kent Osborne et al.

ANNUAL REVIEW OF MEDICINE, VOL 62, 2011 (2011)

Article Oncology

Dependence on the MUC1-C Oncoprotein in Non-Small Cell Lung Cancer Cells

Deepak Raina et al.

MOLECULAR CANCER THERAPEUTICS (2011)

Review Oncology

NF-kappa B, stem cells and breast cancer: the links get stronger

Kateryna Shostak et al.

BREAST CANCER RESEARCH (2011)

Article Biochemistry & Molecular Biology

Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer

N. Khodarev et al.

ONCOGENE (2010)

Article Oncology

MUC1* is a determinant of trastuzumab (Herceptin) resistance in breast cancer cells

Shawn P. Fessler et al.

BREAST CANCER RESEARCH AND TREATMENT (2009)

Article Oncology

Intracellular MUC1 Peptides Inhibit Cancer Progression

Benjamin G. Bitler et al.

CLINICAL CANCER RESEARCH (2009)

Review Cell Biology

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

Bryan T. MacDonald et al.

DEVELOPMENTAL CELL (2009)

Review Oncology

Evolving novel anti-HER2 strategies

Kellie L. Jones et al.

LANCET ONCOLOGY (2009)

Article Multidisciplinary Sciences

MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment

Sean P. Pitroda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Oncology

Mucins in cancer: function, prognosis and therapy

Donald W. Kufe

NATURE REVIEWS CANCER (2009)

Review Oncology

Biological determinants of endocrine resistance in breast cancer

Elizabeth A. Musgrove et al.

NATURE REVIEWS CANCER (2009)

Review Medicine, General & Internal

Drug therapy: Trastuzumab - Mechanism of action and use in clinical practice

Clifford A. Hudis

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Article Biochemistry & Molecular Biology

MUC1 is a novel regulator of erbB1 receptor trafficking

M. R. Pochampalli et al.

ONCOGENE (2007)

Review Biochemistry & Molecular Biology

The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer

R. L. Dillon et al.

ONCOGENE (2007)

Article Multidisciplinary Sciences

Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3

Natalia V. Sergina et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

Mucin 1 oncoprotein blocks hypoxia-inducible factor 1α activation in a survival response to hypoxia

Li Yin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

MUC1 oncoprotein stabilizes and activates estrogen receptor α

XL Wei et al.

MOLECULAR CELL (2006)

Article Cell Biology

MUC1 (CD227) interacts with lck tyrosine kinase in Jurkat lymphoma cells and normal T cells

P Mukherjee et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2005)

Article Biochemistry & Molecular Biology

MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation

JA Schroeder et al.

ONCOGENE (2004)

Review Oncology

Mucins in cancer: Protection and control of the cell surface

MA Hollingsworth et al.

NATURE REVIEWS CANCER (2004)

Article Biochemistry & Molecular Biology

MUC1 oncoprotein activates the FOXO3a transcription factor in a survival response to oxidative stress

L Yin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

The MUC1 oncoprotein activates the anti-apoptotic phosphoinositide 3-kinase/Akt and Bcl-xL pathways in rat 3Y1 fibroblasts

D Raina et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Oncology

Inhibition of MUC1 expression by indole-3-carbinol

IJ Lee et al.

INTERNATIONAL JOURNAL OF CANCER (2004)

Article Biochemistry & Molecular Biology

Human DF3/MUC1 carcinoma-associated protein functions as an oncogene

YQ Li et al.

ONCOGENE (2003)

Article Biochemistry & Molecular Biology

MUC1 alters β-catenin-dependent tumor formation and promotes cellular invasion

JA Schroeder et al.

ONCOGENE (2003)