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Oncology
Joshua R. Veatch et al.
Summary: This study utilized single-cell RNA sequencing to investigate tumor-specific CD4(+) T cells infiltrating human melanoma and identified their phenotypes and functions. The expression of these tumor-specific CD4(+) T cells in the tumor microenvironment correlated with the transcriptional states of CD8(+) T cells and macrophages, maturation of B cells, and patient survival.
Article
Oncology
Chunhong Zheng et al.
Summary: In this study, tumor-infiltrating lymphocytes from bile duct and pancreatic cancer patients were examined using immunological screening and single-cell RNA sequencing. The researchers found that neoantigen-reactive T cells infiltrating gastrointestinal cancers exhibited an exhausted state and had distinct transcriptomic signatures, which could potentially be utilized for therapy.
Article
Immunology
Maxime Meylan et al.
Summary: The presence of intratumoral tertiary lymphoid structures (TLS) is associated with positive clinical outcomes and responses to immunotherapy in renal cell carcinoma (RCC). B cells are enriched in TLS and demonstrate diverse maturation stages, with the presence of fully mature clonotypes. Additionally, IgG-and IgA-producing plasma cells (PCs) disseminate into the tumor beds along fibroblastic tracks in TLS+ tumors, indicating potential anti-tumor effector activity. Furthermore, the presence of IgG-stained tumor cells correlates with therapeutic responses and progression-free survival in RCC patients treated with immune checkpoint inhibitors.
Article
Multidisciplinary Sciences
Frank J. Lowery et al.
Summary: Mapping TCRs from metastatic tumors to single-cell transcriptomes identified tumor-specific expanded neoantigen-specific TILs with dysfunctional phenotypes. Prospectively testing signature-derived clonotypes demonstrated TCR recognition of tumor antigens, suggesting a common metastatic TIL exhaustion program. NeoTCR signatures enable successful TCR prediction for cancer immunotherapy based on TIL transcriptomic states.
Article
Biochemistry & Molecular Biology
Can Cui et al.
Summary: The study found that the enrichment of TFH cell transcriptional signature in lung adenocarcinoma patients is correlated with GC B cell signature and prolonged survival. Interactions between tumor-specific TFH and GC B cells are crucial for tumor control and effector CD8 T cell function.
Article
Biochemistry & Molecular Biology
Kevin Litchfield et al.
Summary: Checkpoint inhibitors (CPIs) enhance adaptive immunity, with clonal tumor mutation burden (TMB) identified as the strongest predictor of CPI response. Dinucleotide variants may serve as a source of immunogenic epitopes, while copy-number alterations and HLA evolutionary divergence lack pan-cancer significance.
Article
Multidisciplinary Sciences
Christiane S. Eberhardt et al.
Summary: The study identified different transcriptional subsets of HPV-specific CD8 T cells in HPV-positive head and neck cancer, highlighting the potential response to PD-1 blockade. Furthermore, the inclusion of E2 and E5 proteins in HPV therapeutic vaccines should be considered to elicit a broader tumor-reactive CD8 T cell response.
Article
Multidisciplinary Sciences
Justina X. Caushi et al.
Summary: Single-cell RNA sequencing and T cell receptor sequencing are combined to identify transcriptional programs specific to mutation-associated neoantigen-specific T cells in non-small cell lung cancers treated with anti-PD-1, providing insights into resistance to PD-1 blockade.
Article
Multidisciplinary Sciences
Giacomo Oliveira et al.
Summary: The authors demonstrate through single-cell profiling and T cell receptor specificity screening that tumour antigen recognition influences the phenotypes of CD8(+) T cells and antitumour immune responses. Non-tumour-reactive T cells show a non-exhausted memory phenotype, while melanoma-reactive lymphocytes exhibit an exhausted state, providing insights into the properties of the anti-melanoma TCR repertoire.
Article
Oncology
Ehsan Ghorani et al.
Article
Biochemistry & Molecular Biology
Alena Gros et al.
