期刊
CANCER AND METASTASIS REVIEWS
卷 41, 期 2, 页码 281-299出版社
SPRINGER
DOI: 10.1007/s10555-022-10026-6
关键词
Esophageal squamous cell carcinoma; Esophageal adenocarcinoma; Inflammation; Microbiome; Tumor microenvironment
类别
资金
- Qatar National Library
- Medical Research Center [16354/16]
- Hamad Medical Corporation, Doha Qatar [A514]
- AIIMS IITD Grant from All India Institute of Medical Sciences (AIIMS) New Delhi, Delhi India [AI-34]
- Sidra Medicine Precision Program [5081012003, 5081012002]
- Qatar National Library, Doha, Qatar
Esophageal cancer is a lethal malignancy and a major cause of cancer-related deaths worldwide. Traditional treatments have limited efficacy and poor prognosis. In addition to the tumor microenvironment, the esophageal microbiome and inflammation also play a significant role in promoting esophageal cancer.
Esophageal cancer (EC) is frequently considered a lethal malignancy and is often identified at a later stage. It is one of the major causes of cancer-related deaths globally. The conventional treatment methods like chemotherapy, radiotherapy, and surgery offer limited efficacy and poor clinical outcome with a less than 25% 5-year survival rate. The poor prognosis of EC persists despite the growth in the development of diagnostic and therapeutic modalities to treat EC. This underlines the need to elucidate the complex molecular mechanisms that drive esophageal oncogenesis. Apart from the role of the tumor microenvironment and its structural and cellular components in tumorigenesis, mounting evidence points towards the involvement of the esophageal microbiome, inflammation, and their cross-talk in promoting esophageal cancer. The current review summarizes recent research that delineates the underlying molecular mechanisms by which the microbiota and inflammation promote the pathophysiology of esophageal cancer, thus unraveling targets for potential therapeutic intervention.
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