4.6 Review

Anti-human platelet antigen-5b antibodies and fetal and neonatal alloimmune thrombocytopenia; incidental association or cause and effect?

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Article Hematology

Clinical characteristics of human platelet antigen (HPA)-1a and HPA-5b alloimmunised pregnancies and the association between platelet HPA-5b antibodies and symptomatic fetal neonatal alloimmune thrombocytopenia

Thijs W. de Vos et al.

Summary: Fetal neonatal alloimmune thrombocytopenia (FNAIT) is a condition caused by maternal alloantibodies targeting human platelet antigens, which can result in severe bleeding in the unborn child. While anti-HPA-1a-mediated FNAIT tends to have a more severe clinical outcome, anti-HPA-5b may also be associated with severe neonatal bleeding symptoms. Further research, including a prospective study, is needed to fully understand the natural history of anti-HPA-5b mediated FNAIT.

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