期刊
BRITISH JOURNAL OF CANCER
卷 127, 期 3, 页码 514-523出版社
SPRINGERNATURE
DOI: 10.1038/s41416-022-01822-6
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资金
- Cancer Foundation Finland [59-5619]
- U.S. National Institutes of Health [R35 CA197735]
- University of Oulu including Oulu University Hospital
This study evaluated the prognostic significance of tumour cell-T cell co-localisation and T cell densities in colorectal cancer patients. The findings showed that high T cell proximity score was associated with longer cancer-specific survival, indicating the potential of spatial measurement of T cell infiltrates as a novel, robust tumour-immune biomarker.
Background Although high T cell density is a strong favourable prognostic factor in colorectal cancer, the significance of the spatial distribution of T cells is incompletely understood. We aimed to evaluate the prognostic significance of tumour cell-T cell co-localisation and T cell densities. Methods We analysed CD3 and CD8 immunohistochemistry in a study cohort of 983 colorectal cancer patients and a validation cohort (N = 246). Individual immune and tumour cells were identified to calculate T cell densities (to derive T cell density score) and G-cross function values, estimating the likelihood of tumour cells being co-located with T cells within 20 mu m radius (to derive T cell proximity score). Results High T cell proximity score associated with longer cancer-specific survival in both the study cohort [adjusted HR for high (vs. low) 0.33, 95% CI 0.20-0.52, P-trend < 0.0001] and the validation cohort [adjusted HR for high (vs. low) 0.15, 95% CI 0.05-0.45, P-trend < 0.0001] and its prognostic value was independent of T cell density score. Conclusions The spatial point pattern analysis of tumour cell-T cell co-localisation could provide detailed information on colorectal cancer prognosis, supporting the value of spatial measurement of T cell infiltrates as a novel, robust tumour-immune biomarker.
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