☆ 4.6 Editorial Material

The drug titration paradox: something obvious finally understood

BRITISH JOURNAL OF ANAESTHESIA (2022)

Beware the drug titration paradox. Comment on Br J Anaesth 2021; 127: 704-12

Thomas W. Schnider et al.

BRITISH JOURNAL OF ANAESTHESIA (2022)

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Article Anesthesiology

Relationship Between Propofol Target Concentrations, Bispectral Index, and Patient Covariates During Anesthesia

Thomas W. Schnider et al.

Summary: This study found considerable variability in propofol effect-site concentrations titrated to BIS in real-world conditions, with patient demographic factors explaining only a small portion of the remaining variability in drug response.

ANESTHESIA AND ANALGESIA (2021)

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Article Pharmacology & Pharmacy

The Drug Titration Paradox: Correlation of More Drug With Less Effect in Clinical Data

Thomas W. Schnider et al.

Summary: The study found a negative correlation between dose and effect in clinical data, and identified two additional factors contributing to this paradox through simulations.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

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Editorial Material Pharmacology & Pharmacy

The Titration Paradox Turns Pharmacology Upside Down

Steven L. Shafer et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

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Editorial Material Anesthesiology

The quagmire of postoperative delirium: does dose matter?

Amy Gaskell et al.

BRITISH JOURNAL OF ANAESTHESIA (2021)

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Article Anesthesiology

Anaesthetic depth and delirium after major surgery: a randomised clinical trial

Lisbeth A. Evered et al.

Summary: The study found that targeting light anesthesia in patients undergoing major surgery reduced the risk of postoperative delirium and cognitive impairment at 1 year compared to targeting deep anesthesia.

BRITISH JOURNAL OF ANAESTHESIA (2021)

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Editorial Material Anesthesiology

Anaesthetic depth and delirium: a challenging balancing act

Elizabeth L. Whitlock et al.

Summary: The study found that targeting deep anesthesia in patients undergoing major noncardiac surgery was not associated with significantly increased postoperative death or major morbidity, but it significantly increased delirium incidence. The findings may be affected by subpopulation-based differences in patients.

BRITISH JOURNAL OF ANAESTHESIA (2021)

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Letter Pharmacology & Pharmacy

The Drug Titration Paradox is Simpson's Paradox

Gabriel Schamberg et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

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The drug titration paradox: something obvious finally understood

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