期刊
BRAIN PATHOLOGY
卷 32, 期 5, 页码 -出版社
WILEY
DOI: 10.1111/bpa.13058
关键词
autophagy; glioblastoma; neurodegeneration; p62; Tau
资金
- WWTF Life Science Project [20-034]
- Hochschuljubilaumsstiftung der Stadt Wien [H-283459/2019]
- Medizinisch-Wissenschaftlicher Fonds des Burgermeisters der Bundeshauptstadt Wien [18097]
Neurodegenerative diseases pose a significant health burden, and their underlying mechanisms are not fully understood. This study found enhanced autophagy and deposition of neurodegeneration-associated proteins within and around glioblastoma tumor cells, suggesting a preexisting neurodegenerative pathology rather than a tumor-induced condition.
Neurodegenerative diseases are a major health burden. The underlying causes are not yet fully understood, but different mechanisms such as cell stress and chronic inflammation have been described as contributing factors. Neurodegenerative changes have been observed in the vicinity of brain tumors, typically around slowly growing benign lesions. Moreover, in-vitro data suggest a potential induction of pathological tau deposits also in glioblastoma, a highly malignant and proliferative brain cancer. The aim of this study was to evaluate neurodegeneration-associated protein deposition and autophagy as well as microglial activation within and surrounding glioblastoma. Post-mortem brain tissue of 22 patients with glioblastoma was evaluated immunohistochemically for phosphorylated tau, beta-amyloid, alpha-synuclein and phosphorylated TDP-43. Additionally, the autophagy marker p62 and the microglial marker HLA-DR were investigated. The data was compared to 22 control cases and ten cases with other space occupying brain lesions. An increase of p62-immunoreactivity was observed within and adjacent to the glioblastoma tumor tissue. Moreover, dense microglial infiltration in the tumor tissue and the immediate surrounding brain tissue was a constant feature. Deposition of neurodegeneration-associated proteins was found in the majority of cases (86.4%) but in distant sites. These findings suggested a preexisting neurodegenerative pathology, which followed a typical distributional pattern: ten cases with Alzheimer disease neuropathological changes, including two severe cases, eight cases with primary age-related tauopathy, six cases with aging-related tau astrogliopathy and one case with progressive supranuclear palsy. Collectively, our data suggests enhanced autophagy in glioblastoma tumor cells and the surrounding brain. The variety and distribution of distant neurodegeneration-associated protein aggregates observed in the majority of cases, suggest a preexisting rather than a tumor-induced neurodegenerative condition.
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