期刊
BRAIN PATHOLOGY
卷 32, 期 5, 页码 -出版社
WILEY
DOI: 10.1111/bpa.13071
关键词
cathepsin B; central nervous system; leakage; lysosome; neurodegeneration; neuron development
资金
- Beijing Natural Science Foundation [7212066]
- Clinical Medicine +X Research Project of Affiliated Hospital of Qingdao University [QDFY+X2021055]
- National Natural Science Foundation of China [32070954]
- Shandong Provincial Natural Science Foundation Youth Project [ZR2021QH251]
This review summarizes the physiological and pathological functions of CatB in the central nervous system and discusses its potential therapeutic applications.
Cathepsin B (CatB) is a typical cysteine lysosomal protease involved in a variety of physiologic and pathological processes. It is expressed in most cell types and is primarily localized within subcellular endosomal and lysosomal compartments. Emerging scientific evidence indicates that lysosomal leaked CatB is involved in mitochondrial stress, inflammasome activation, and nuclear senescence, but without the acidic environment. CatB is also secreted as a myokine, which is involved in muscle-brain cross talk and neuronal dendritic remodeling. Lysosomal-leaked and cellular-secreted CatB functions are dependent on its enzymatic activity at a neutral pH. In the present review, we summarize the available experimental evidence that mechanistically links extralysosomal CatB to physiological and pathological functions in central nervous system, and their potential for use in therapeutic approaches.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据