4.5 Article

Aberrant functional connectivity in insular subregions in somatic depression: a resting-state fMRI study

期刊

BMC PSYCHIATRY
卷 22, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s12888-022-03795-5

关键词

Somatic depression; Ventral anterior insula; Dorsal anterior insula; Posterior insula; Resting-state functional connectivity

资金

  1. National Natural Science Foundation of China [81871066]
  2. Jiangsu Provincial key research and development program [BE2018609, BE2019675]
  3. Jiangsu Provincial Medical Innovation Team of the Project of Invigorating Health Care through Science, Technology and Education [CXTDC2016004]
  4. Jiangsu Provincial Medical Youth Talent of the Project of Invigorating Health Care through Science, Technology and Education [QNRC2016050]
  5. Medical Science and Technology development Foundation
  6. Jiangsu Commission of Health [K2019011]
  7. Humanities and social sciences research fund project of the ministry of education [17YJA740023]

向作者/读者索取更多资源

This study found significant differences in functional connectivity between insular subregions and other brain regions in SD patients compared to NSD patients, which may be related to cognitive impairment in SD patients. Additionally, there were no significant differences in functional connectivity between bilateral posterior insula and any brain regions among the SD, NSD, and HC groups.
Background Somatic depression (SD) is different from non-somatic depression (NSD), and insular subregions have been associated with somatic symptoms. However, the pattern of damage in the insular subregions in SD remains unclear. The aim of this study was to use functional connectivity (FC) analyses to explore the bilateral ventral anterior insula (vAI), bilateral dorsal anterior insula (dAI), and bilateral posterior insula (PI) brain circuits in SD patients. Methods The study included 28 SD patients, 30 NSD patients, and 30 matched healthy control (HC) subjects. All participants underwent 3.0 T resting state functional magnetic resonance imaging. FC analyses were used to explore synchronization between insular subregions and the whole brain in the context of depression with somatic symptoms. Pearson correlation analyses were performed to assess relationships between FC values in brain regions showing significant differences and the total and factor scores on the 17-item Hamilton Rating Scale for Depression (HAMD(17)). Results Compared with the NSD group, the SD group showed significantly decreased FC between the left vAI and the right rectus gyrus, right fusiform gyrus, and right angular gyrus; between the right vAI and the right middle cingulate cortex, right precuneus, and right superior frontal gyrus; between the left dAI and the left fusiform gyrus; and between the right dAI and the left postcentral gyrus. Relative to the NSD group, the SD group exhibited increased FC between the left dAI and the left fusiform gyrus. There were no differences in FC between bilateral PI and any brain regions among the SD, NSD, and HC groups. Within the SD group, FC values between the left vAI and right rectus gyrus were positively correlated with cognitive impairment scores on the HAMD(17); FC values between the right vAI and right superior frontal gyrus were positively related to the total scores and cognitive impairment scores on the HAMD(17) (p < 0.05, uncorrected). Conclusions Aberrant FC between the anterior insula and the frontal and limbic cortices may be one possible mechanism underlying SD.

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