期刊
BMC MUSCULOSKELETAL DISORDERS
卷 23, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12891-022-05128-9
关键词
Osteoarthritis; Exercise; Physical activity; Weight management; Ketogenic diet; Hip; Pain; Obesity
资金
- National Health and Medical Research Council Investigator Grant [1774431]
- Centre of Research Excellence Grant [1079078]
- NHMRC [1172928, 1178482, 1154217, 1174431, 1194737, APP1194829]
- National Health and Medical Research Council of Australia [1154217, 1172928, 1174431, 1178482, 1194737] Funding Source: NHMRC
This study aims to compare the effectiveness of a combined diet and exercise program with an exercise-only program in relieving hip pain. The study will use a randomized controlled trial to evaluate the effects of the two programs and measure multiple outcomes, including pain, body weight, physical function, and quality of life. The results will provide evidence-based advice for clinicians regarding the effect of a dietary intervention on hip osteoarthritis pain.
Background: Hip osteoarthritis (OA) is a leading cause of musculoskeletal pain. Exercise is a core recommended treatment. Despite some clinical guidelines also recommending weight loss for hip OA, there is no evidence from . randomised controlled trials (RCT) to substantiate these recommendations. This superiority, 2-group, parallel RCT will compare a combined diet and exercise program to an exercise only program, over 6 months. Methods: One hundred people with symptomatic and radiographic hip OA will be recruited from the community. Following baseline assessment, participants will be randomly allocated to either, i) diet and exercise or; ii) exercise only. Participants in the diet and exercise group will have six consultations with a dietitian and five consultations with a physiotherapist via videoconferencing over 6 months. The exercise only group will have five consultations with a physiotherapist via videoconferencing over 6 months. The exercise program for both groups will include prescription of strengthening exercise and a physical activity plan, advice about OA management and additional educational resources. The diet intervention includes prescription of a ketogenic very low-calorie diet with meal replacements and educational resources to support weight loss and healthy eating. Primary outcome is self-reported hip pain via an 11-point numeric rating scale (0='no pain' and 10 ='worst pain possible') at 6 months. Secondary outcomes include self-reported body weight (at 0, 6 and 12 months) and body mass index (at 0, 6 and 12 months), visceral fat (measured using dual energy x-ray absorptiometry at 0 and 6 months), pain, physical function, quality of life (all measured using subscales of the Hip Osteoarthritis Outcome Scale at 0, 6 and 12 months), and change in pain and physical activity (measured using 7-point global rating of change Likert scale at 6 and 12 months). Additional measures include adherence, adverse events and cost-effectiveness. Discussion: This study will determine whether a diet intervention in addition to exercise provides greater hip pain-relief, compared to exercise alone. Findings will assist clinicians in providing evidence-based advice regarding the effect of a dietary intervention on hip OA pain.
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