4.5 Article

Interleukin-6 and granulocyte colony-stimulating factor as predictors of the prognosis of influenza-associated pneumonia

期刊

BMC INFECTIOUS DISEASES
卷 22, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s12879-022-07321-6

关键词

Influenza; Pneumonia; Cytokine; Interleukin-6; Granulocyte colony-stimulating factor; Neutrophil

资金

  1. National Natural Science Foundation of China Program [81872672]
  2. National High Technology Research and Development Program of China [2020YFE0204300]
  3. National Science and Technology Major Project [2017ZX10204401]

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This study found that IL-6 and G-CSF levels were strongly correlated with poor prognosis and severity of influenza-associated pneumonia. These cytokines can serve as important predictors for evaluating the prognosis and severity of pneumonia in influenza patients.
Background Pneumonia is a common complication of influenza and closely related to mortality in influenza patients. The present study examines cytokines as predictors of the prognosis of influenza-associated pneumonia. Methods This study included 101 inpatients with influenza (64 pneumonia and 37 non-pneumonia patients). 48 cytokines were detected in the serum samples of the patients and the clinical characteristics were analyzed. The correlation between them was analyzed to identify predictive biomarkers for the prognosis of influenza-associated pneumonia. Results Seventeen patients had poor prognosis and developed pneumonia. Among patients with influenza-associated pneumonia, the levels of 8 cytokines were significantly higher in those who had a poor prognosis: interleukin-6 (IL-6), interferon-gamma (IFN-gamma), granulocyte colony-stimulating factor (G-CSF), monocyte colony-stimulating factor (M-CSF), monocyte chemoattractant protein-1 (MCP-1), monocyte chemoattractant protein-3, Interleukin-2 receptor subunit alpha and Hepatocyte growth factor. Correlation analysis showed that the IL-6, G-CSF, M-CSF, IFN-gamma, and MCP-1 levels had positive correlations with the severity of pneumonia. IL-6 and G-CSF showed a strong and positive correlation with poor prognosis in influenza-associated pneumonia patients. The combined effect of the two cytokines resulted in the largest area (0.926) under the receiver-operating characteristic curve. Conclusion The results indicate that the probability of poor prognosis in influenza patients with pneumonia is significantly increased. IL-6, G-CSF, M-CSF, IFN-gamma, and MCP-1 levels had a positive correlation with the severity of pneumonia. Importantly, IL-6 and G-CSF were identified as significant predictors of the severity of influenza-associated pneumonia.

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