期刊
BMC CANCER
卷 22, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12885-022-09352-3
关键词
Intrahepatic cholangiocarcinoma; Machine learning; Survival; Modelling; Surgery
类别
资金
- Key Program of the National Natural Science Foundation of China [31930020]
- National Natural Science Foundation of China [82102150]
- Natural Science Foundation of Jiangsu Province [BK20210968]
This study aimed to establish a novel model using machine learning technique to predict survival in patients with surgically resected intrahepatic cholangiocarcinoma (ICC) based on readily-available clinical parameters. The gradient boosting machine (GBM) model showed superior performance in predicting cancer-specific survival (CSS) compared to other prognostic indices. The GBM model can be integrated into a decision-support electronic health record system to improve therapeutic strategies for patients with resected ICC.
Background Accurate prognosis assessment is essential for surgically resected intrahepatic cholangiocarcinoma (ICC) while published prognostic tools are limited by modest performance. We therefore aimed to establish a novel model to predict survival in resected ICC based on readily-available clinical parameters using machine learning technique. Methods A gradient boosting machine (GBM) was trained and validated to predict the likelihood of cancer-specific survival (CSS) on data from a Chinese hospital-based database using nested cross-validation, and then tested on the Surveillance, Epidemiology, and End Results (SEER) database. The performance of GBM model was compared with that of proposed prognostic score and staging system. Results A total of 1050 ICC patients (401 from China and 649 from SEER) treated with resection were included. Seven covariates were identified and entered into the GBM model: age, tumor size, tumor number, vascular invasion, number of regional lymph node metastasis, histological grade, and type of surgery. The GBM model predicted CSS with C-Statistics >= 0.72 and outperformed proposed prognostic score or system across study cohorts, even in sub-cohort with missing data. Calibration plots of predicted probabilities against observed survival rates indicated excellent concordance. Decision curve analysis demonstrated that the model had high clinical utility. The GBM model was able to stratify 5-year CSS ranging from over 54% in low-risk subset to 0% in high-risk subset. Conclusions We trained and validated a GBM model that allows a more accurate estimation of patient survival after resection compared with other prognostic indices. Such a model is readily integrated into a decision-support electronic health record system, and may improve therapeutic strategies for patients with resected ICC.
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