4.6 Article

LINC00511 enhances LUAD malignancy by upregulating GCNT3 via miR-195-5p

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miR-195-5p exerts tumor-suppressive functions in human lung cancer cells through targeting TrxR2

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Summary: The microRNA miR-195-5p acts as a tumor suppressor in lung adenocarcinoma (LUAD) cells by targeting TrxR2, leading to inhibition of cell proliferation, migration, and invasion, as well as induction of apoptosis. Knockdown of TrxR2 mimics the tumor-suppressive effects of miR-195-5p overexpression, while overexpression of TrxR2 reverses these effects in A549 and PC-9 cells. Additionally, miR-195-5p overexpression inhibits the growth of xenografted A549 tumors in nude mice, suggesting its potential as a biomarker for LUAD therapy.

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