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GATA1: function through disorder

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BLOOD
卷 139, 期 16, 页码 2422-2423

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AMER SOC HEMATOLOGY
DOI: 10.1182/blood.2021015351

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In this article, Ludwig et al characterize a rare form of inherited hemolytic anemia and identify novel mutations in an intrinsically disordered region (IDR) in the GATA1 carboxyl (C)-terminal domain. These mutations have novel functions in selectively regulating GATA1 chromatin occupancies in erythropoiesis.
In this issue of Blood, Ludwig et al characterize a rare form of inherited hemolytic anemia. They identified novel mutations in an intrinsically disordered region (IDR) in the GATA1 carboxyl (C)-terminal domain, which underlie novel functions in selectively regulating GATA1 chromatin occupancies in erythropoiesis.(1)

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