In this study, Ishio et al identified the crucial genes and the importance of the mTORC1 pathway in the proliferation and survival of adult T-cell leukemia-lymphoma (ATL) cells using whole-genome CRISPR library screening.
In this issue of Blood, Ishio et al(1) identified the genes critical for proliferation and/or survival of adult T-cell leukemia-lymphoma (ATL) cells using wholegenome CRISPR library screening. They also discovered that the mTORC1 pathway is critical for ATL cells.
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