GVHD ... it is all about the microenvironment!

In this issue of Blood, Zaiken et al describe the impact on chronic graft-versus-host disease (cGVHD) affecting the formation of germinal centers (GCs) in secondary lymphoid organs (SLOs).(1) Using 2 different small molecules targeting polycomb repressive complex 2 (PRC2) or bromodomain and extraterminal (BET)-bromodomain inhibitor, they demonstrate both can improve cGVHD in a murine model of bronchiolitis obliterans (BO) and one also improved scleroderma in another model.

Automated summary

In this article, the impact of chronic graft-versus-host disease on the formation of germinal centers is described. Using different small molecules, the study demonstrates the improvement of related disease models.