4.6 Article

Whole-exome sequencing uncovers new variants in GDF15 associated with hyperemesis gravidarum

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Genetics & Heredity

The Heidelberg Five personality dimensions: Genome-wide associations, polygenic risk for neuroticism, and psychopathology 20 years after assessment

Urs Heilbronner et al.

Summary: The HeiDE study identified five health-related personality dimensions, with emotional lability, lack of behavioral control, and psychoticism being associated with depressive symptoms. LBCN was identified as a heritable executive function personality trait.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2021)

Article Endocrinology & Metabolism

Growth-differentiation-factor 15 levels in obese and healthy pregnancies: Relation to insulin resistance and insulin secretory function

Ulrika Andersson-Hall et al.

Summary: This study found that GDF15 levels significantly increased during pregnancy and were associated with factors such as BMI, fat-free mass, incidence of nausea, and fetal sex. The upregulation of GDF15 during pregnancy was associated with increased HOMA-B in women with obesity and reduced fasting glucose in all women.

CLINICAL ENDOCRINOLOGY (2021)

Article Endocrinology & Metabolism

Exome Sequencing of 21 Bardet-Biedl Syndrome (BBS) Genes to Identify Obesity Variants in 6,851 American Indians

Samantha E. Day et al.

Summary: This study reports potentially functional variants in BBS genes in American Indians, but the functional evidence supporting a causal role for BBS9 in obesity is inconclusive.

OBESITY (2021)

Article Multidisciplinary Sciences

GFRAL-expressing neurons suppress food intake via aversive pathways

Paul Sabatini et al.

Summary: GDF-15 activates GFRAL neurons, affecting the expression of neurotransmitters and neuropeptides, thereby inhibiting feeding and gastric emptying, promoting conditioned taste aversion; neurons with the strongest effect innervate the PBN and target CGRP(PBN) neurons, silencing of which abolishes the negative and anorectic effects of GDF-15.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation

Ella Fung et al.

Summary: GDF15, a distant member of the TGF-beta family, has shown potential as a therapeutic for treating obesity and its associated metabolic diseases. Challenges in its development include short half-life, high aggregation propensity, and protease susceptibility. Through structure-based engineering, a new therapeutic format for GDF15 has been developed with improved efficacy and potential for better manufacturability.

SCIENTIFIC REPORTS (2021)

Review Endocrinology & Metabolism

Growth differentiation factor 15 as a potential therapeutic for treating obesity

Clarence Hale et al.

Summary: Obesity has become a major global health concern, especially in developing countries where resources for surgical treatments are limited. There is a need for safe and effective pharmacological therapies. Recent research suggests that GDF15 holds promise as a novel anti-obesity treatment.

MOLECULAR METABOLISM (2021)

Meeting Abstract Obstetrics & Gynecology

Additional risk variant in GDF15 and a stronger maternal genetic influence linked to Hyperemesis Gravidarum

Patrick Mullin et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2020)

Article Cell Biology

GDF15 Induces Anorexia through Nausea and Emesis

Tito Borner et al.

CELL METABOLISM (2020)

Review Endocrinology & Metabolism

GDF15: A Hormone Conveying Somatic Distress to the Brain

Samuel M. Lockhart et al.

ENDOCRINE REVIEWS (2020)

Article Biochemistry & Molecular Biology

Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice

Rowena Suriben et al.

NATURE MEDICINE (2020)

Article Physiology

The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?

Samuel N. Breit et al.

Annual Review of Physiology (2020)

Article Oncology

Integrated Informatics Analysis of Cancer-Related Variants

Kymberleigh A. Pagel et al.

JCO CLINICAL CANCER INFORMATICS (2020)

Article Obstetrics & Gynecology

Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality

Marlena S. Fejzo et al.

GEBURTSHILFE UND FRAUENHEILKUNDE (2019)

Article Medicine, General & Internal

Nausea and vomiting of pregnancy and hyperemesis gravidarum

Marlena S. Fejzo et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

Meeting Abstract Obstetrics & Gynecology

Hormone receptor genes PGR and GFRAL linked to hyperemesis gravidarum

Marlena Fejzo et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2019)

Article Endocrinology & Metabolism

Elevated Serum Growth Differentiation Factor 15 Levels in Hyperthyroid Patients

Jiejie Zhao et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

Review Oncology

Cancer cachexia: Diagnosis, assessment, and treatment

Mohammadamin Sadeghi et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2018)

Article Multidisciplinary Sciences

Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

Marlena S. Fejzo et al.

NATURE COMMUNICATIONS (2018)

Article Obstetrics & Gynecology

Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum

Marlena S. Fejzo et al.

GEBURTSHILFE UND FRAUENHEILKUNDE (2018)

Article Biochemistry & Molecular Biology

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

Linda Yang et al.

NATURE MEDICINE (2017)

Article Biochemistry & Molecular Biology

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

Shannon E. Mullican et al.

NATURE MEDICINE (2017)

Article Biochemistry & Molecular Biology

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

Paul J. Emmerson et al.

NATURE MEDICINE (2017)

Article Cell Biology

Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys

Yumei Xiong et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Geriatrics & Gerontology

MAP3K11/GDF15 axis is a critical driver of cancer cachexia

Lorena Lerner et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2016)

Article Medical Laboratory Technology

Clinical and Genetic Correlates of Growth Differentiation Factor 15 in the Community

Jennifer E. Ho et al.

CLINICAL CHEMISTRY (2012)

Article Endocrinology & Metabolism

The H6D variant of NAG-1/GDF15 inhibits prostate xenograft growth in vivo

Xingya Wang et al.

PROSTATE (2012)

Article Public, Environmental & Occupational Health

Practical and analytical aspects of using friend controls in case-control studies: experience from a case-control study of childhood cancer

Greta R. Bunin et al.

PAEDIATRIC AND PERINATAL EPIDEMIOLOGY (2011)

Article Biochemistry & Molecular Biology

Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1

Heiko Johnen et al.

NATURE MEDICINE (2007)

Article Obstetrics & Gynecology

Nausea and vomiting of pregnancy in an evolutionary perspective

PW Sherman et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2002)