期刊
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
卷 70, 期 1, 页码 330-343出版社
WILEY
DOI: 10.1002/bab.2355
关键词
chitosan; copper sulfide; cytarabine; drug delivery; N-hydroxysuccinimide; surface modification
In this study, CuS nanoparticles modified by CS and FA were successfully synthesized and used as nanocarriers for the delivery of the anticancer drug CYT. The results showed that CYT/CuS NPs-CS-FA can be proposed as an efficient nanocarrier for the targeted delivery of anticancer drugs.
Nanoparticles (NPs) have gained more attention as drug delivery systems. Folic acid (FA)-chitosan (CS) conjugates, because of their biodegradability, low toxicity, and better stability, offer a pharmaceutical drug delivery tool. The aim of this work was to fabricate CuS NPs modified by CS followed by grafting FA as a nanocarrier for the delivery of cytarabine (CYT) as an anticancer drug. In this work, CuS NPs modified by CS and FA were successfully synthesized. The structural properties of the nanocarrier were characterized by using scanning electron microscopy, Fourier transform infrared, X-ray diffraction, thermogravimetric analysis, and Brunauer-Emmett-Teller. The adsorption mechanism of CYT by adsorption isotherms, kinetics, and thermodynamics was deliberated and modeled. The in vitro CYT release behavior for the nanocarrier was 99% and 61% at pH 5.6 and 7.4, respectively. The adsorption behavior of CYT by CuS NPs-CS-FA was well explored by pseudo-second-order kinetic and Langmuir isotherm models by the coefficient of determination (R-2 > 0.99). Thermodynamic results showed that the uptake of CYT by CuS NPs-CS-FA was endothermic and spontaneous. The experimental results showed that CYT/CuS NPs-CS-FA can be proposed as an efficient nanocarrier for the targeted delivery of anticancer drugs.
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