4.6 Review

Are PARPs promiscuous?

期刊

BIOSCIENCE REPORTS
卷 42, 期 5, 页码 -

出版社

PORTLAND PRESS LTD
DOI: 10.1042/BSR20212489

关键词

-

资金

  1. START program of the Medical Faculty of RWTH Aachen University [3/20]
  2. Deutsche Forschungsgemeinschaft [FE 1423/3-1]

向作者/读者索取更多资源

Post-translational modifications play a crucial role in regulating cell health. The PARP family enzymes can transfer ADP-ribose to their targets, and recent studies have expanded the list of potential acceptor amino acids. While PARylation by PARP1 is well studied, knowledge about other family members such as PARP7 and PARP10 is limited. Understanding the biochemical reactions and biological functions of PARPs is important for future research.
Post-translational modifications exist in different varieties to regulate diverse characteristics of their substrates, ultimately leading to maintenance of cell health. The enzymes of the intracellular poly(ADP-ribose) polymerase (PARP) family can transfer either a single ADP-ribose to targets, in a reaction called mono(ADP-ribosyl)ation or MARylation, or multiple to form chains of poly(ADP-ribose) or PAR. Traditionally thought to be attached to arginine or glutamate, recent data have added serine, tyrosine, histidine and others to the list of potential ADP-ribose acceptor amino acids. PARylation by PARP1 has been relatively well studied, whereas less is known about the other family members such as PARP7 and PARP10. ADP-ribosylation on arginine and serine is reversed by ARH1 and ARH3 respectively, whereas macrodomain-containing MACROD1, MACROD2 and TARG1 reverse modification of acidic residues. For the other amino acids, no hydrolases have been identified to date. For many PARPs, it is not clear yet what their endogenous targets are. Better understanding of their biochemical reactions is required to be able to determine their biological functions in future studies. In this review, we discuss the current knowledge of PARP specificity in vitro and in cells, as well as provide an outlook for future research.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据