期刊
BIOORGANIC CHEMISTRY
卷 122, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2022.105737
关键词
Nonalcoholic steatohepatitis; Dihydroartemisinin; Endoplasmic reticulum stress; Oxidative stress
资金
- National Natural Science Foundation of China [82170587]
- Luzhou Municipal People's GovernmentSouthwest Medical University Science and Technology Strategic Cooperation Project [2020LZXNYDZ07, 2015LZCYD-S08]
- Hubei Province Chen Xiaoping Science and Technology Development Foundation [CXPJJH11900001-2019339]
- Southwest Medical University Basic Research Project [2021ZKMS026]
- Southwestern Medical University-Luzhou Hospital of Traditional Chinese Medicine Basic Project [2019-LH015]
- Southwestern Medical University Climbing Plan
This study demonstrates the effectiveness of Dihydroartemisinin (DHA) in reducing inflammation and liver steatosis in Nonalcoholic Steatohepatitis (NASH). DHA achieves this by inhibiting endoplasmic reticulum stress and reducing the production of reactive oxygen species. The study reveals the potential of DHA as a treatment option for NASH.
Nonalcoholic steatohepatitis (NASH) is a severely inflammatory subtype of nonalcoholic fatty liver. Endoplasmic reticulum stress (ERS) and oxidative stress (OS) cause metabolic abnormalities, promote liver steatosis and inflammation, and are central to the development of NASH. Dihydroartemisinin (DHA) is a compound extracted from Artemisia annua that is often used in the treatment of malaria. Recent studies have shown that DHA also has a wide range of pharmacological effects, acting on various organs throughout the body to exert antiinflammatory, antioxidant, and anti-fibrotic effects. In this study, we demonstrated in vitro that the antiinflammatory effect of DHA is effective against NASH and reduces liver steatosis. DHA treatment decreased the synthesis of lipids, such as cholesterol and free fatty acids, and the expression of nuclear factor kappa-B. This is accomplished by inhibiting the unfolded protein response and reducing the production of reactive oxygen species, thereby inhibiting OS and ERS. This study reveals DHA's therapeutic effect and potential mechanism in NASH, implying that DHA could be a new and promising candidate for NASH therapy.
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