Diazepinone HBV capsid assembly modulators

The HBV capsid core protein serves a number of important functions in the viral life cycle enabling chronic HBV infection to persist, and therefore is a promising drug target. Interfering with capsid assembly has shown efficacy in clinical trials with small molecule capsid assembly modulators (CAMs). Herein is described the further opti-mization of a progressive series of diazepinone HBV CAMs.

Automated summary

The HBV capsid core protein plays crucial roles in the viral life cycle and is a potential drug target for treating chronic HBV infection. The optimization of diazepinone HBV CAMs, which interfere with capsid assembly, is described in this study.