期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 150, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2022.112971
关键词
Long non-coding RNA; MIR4435-2HG; Prognosis; Cellular process; Signaling pathway
资金
- Leading Talents of Zhongyuan Science and Technology Innovation [214200510027]
- Henan Provincial Medical Science and Technology Research Plan [SBGJ2018002, SBGJ202102117]
- Henan Medical Science and Technology Joint Building Program [LHGJ20210324]
- Science and Technology Innovation Talents in Henan Universities [19HASTIT003]
- Outstanding Foreign Scientist Studio in Henan Province [GZS2020004]
- Gandan Xiangzhao Research Fund [GDXZ2022002]
Long non-coding RNAs have important roles in tumor occurrence and progression, with MIR4435-2HG being crucial in various types of cancers. This review summarizes recent research findings on the expression, functions, mechanism, and clinical value of MIR4435-2HG in cancer, serving as a reference for further research and clinical trials related to MIR4435-2HG.
Long non-coding RNAs (lncRNAs) play important roles in the occurrence and progression of tumors. Extensive research has contributed to the current understanding of the critical roles played by lncRNAs in various cancers. LncRNA MIR4435-2HG has been found to be crucial in many cancers, such as breast, cervical, colorectal, and gastric cancer. Expression of MIR4435-2HG is generally upregulated in cancers and MIR4435-2HG participates in many biological functions through molecular mechanism of competitive endogenous RNA networks. This review profiles recent research findings on the expression, functions, mechanism, and clinical value of MIR4435-2HG in cancer, and serves as a reference for further MIR4435-2HG-related research and clinical trials.
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