期刊
BIOMATERIALS
卷 283, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2022.121472
关键词
MOF@COF; Microwave sensitization; Dynamic therapy; Thermal therapy; Tumor anti-angiogenesis
资金
- National Key R&D Program of China [2020YFE0100200]
- National Natural Science Foundation of China [U20A20335, 81971745, 91859201, 61975214, 61961033]
- Beijing Natural Science Foundation [2202057, 7212208, 4202075]
- Beijing New Star Program of Science and Technology [Z191100001119042]
- International Partnership Program of Chinese Academy of Science [1A1111KYSB20190072]
- Sichuan Science and Technology Program [2020YFSY0018]
This study proposes an integrated strategy derived from MOF@COF for remarkably augmenting single MWTT to reduce tumor recurrence.
Microwave thermal therapy (MWTT) shows great prospect in cancer treatments due to its non-invasive or minimally invasive nature and deep penetration through the tissue. However, incomplete ablation and elevated expression of many pro-tumor angiogenesis after MWTT (e.g., vascular endothelial growth factor, VEGF) induced tumor recurrence still remains an obstacle, especially in some tumors prone to recurrence and metastasis, such as colorectal cancer. Herein, we propose a nanocapsule of covalent organic framework cladding metal organic framework (MOF@COF) with microwave (MW) thermal-dynamic sensitization and co-action of tumor anti-angiogenesis. The MOF of Bi-Mn-porphyrin (BM) is designed as MW sensitizer to generate cytotoxic O-1(2) and heat for microwave dynamic therapy (MWDT) synergistic MWTT. The COF is covalently coated on BM for further augmenting these two sensitization properties, as well as loading hydrophobic inhibitor of Apatinib to down-regulate the expression of VEGF for inhibiting tumor recurrence. Furthermore, the contained Bi and porphyrin endow system with CT and fluorescence imaging (FI) capabilities. In vivo experiments verify that this combi-nation therapy significantly impairs the growth of colorectal cancer with no recurrent carcinoma. Therefore, our work presents an integrated strategy derived from MOF@COF for remarkably augmenting single MWTT to reduce tumor recurrence.
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