期刊
IUBMB LIFE
卷 68, 期 8, 页码 629-633出版社
WILEY
DOI: 10.1002/iub.1520
关键词
renal cell carcinoma; CXCR3 and CXCR2; metastasis; survival; immunohistochemistry
Renal cell carcinoma (RCC) represents, on average, over 90% of all malignancies of the kidney that occur in adults in both sexes. Chemokine receptors expression has been found in many kinds of cancer and at tumor metastasis site. We determined CXCR2 and CXCR3 expression in RCC by immunohistochemistry method and analyzed the prognostic value of these markers. Our finding demonstrated that CXCR3 were highly overexpressed in renal cancer tissues compared with those adjacent normal kidney tissues (P<0.001). The results showed that high expression of CXCR3 was markedly correlated with metastasis (P=0.021) and tumor stage (P=0.031). CXCR2 were overexpressed in renal cancer tissues compared with those adjacent normal kidney tissues (P<0.001). Our result showed that CXCR2 expression was correlated with high grade (P=0.024), advanced stage (P=0.029) and metastasis (P=0.018). The log-rank test revealed that high CXCR2 and CXCR3 expressions are related to poorer overall survival (P<0.001; P<0.001). In conclusion, this study indicates the correlation of CXCR3 and CXCR3 with progression of RCC. In addition, high CXCR3 andCXCR2 expressions were correlated with shorter overall survival. (c) 2016 IUBMB Life, 68(8):629-633, 2016
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据