期刊
BIOLOGICAL PSYCHOLOGY
卷 171, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.biopsycho.2022.108345
关键词
Young Adults; Major Depressive Disorder; Event-Related Potentials; P3; Twin Study
资金
- National Institute on Alcohol Abuse and Alcoholism [R37AA012502, R01AA08315]
- Academy of Finland [1211486, 118555, 100499]
- Finnish Cultural Foundation
- NIDCD [R01DC016765, R01DC016915, R01DC017991]
- Academy of Finland (AKA) [118555, 118555] Funding Source: Academy of Finland (AKA)
This study found that individuals with a history of lifetime major depression still exhibit abnormalities in auditory P3 event-related potential (ERP) after recovery. Substance use in young adults may also have an influence on this association.
Major depression is associated with alterations in the auditory P3 event-related potential (ERP). However, the persistence of these abnormalities after recovery from depressive episodes, especially in young adults, is not well known. Furthermore, the potential influence of substance use on this association is poorly understood. Young adult twin pairs (N = 177) from the longitudinal FinnTwin16 study were studied with a psychiatric interview, and P3a and P3b ERPs elicited by task-irrelevant novel sounds and targets, respectively. Dyadic linear mixed effect models were used to distinguish the effects of lifetime major depressive disorder from familial factors and effects of alcohol problem drinking and tobacco smoking. P3a amplitude was significantly increased and P3b latency decreased, in individuals with a history of lifetime major depression, when controlling the fixed effects of alcohol abuse, tobacco, gender, twins' birth order, and zygosity. These results suggest that past lifetime major depressive disorder may be associated with enhanced attentional sensitivity.
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