Modeling multi-scale data via a network of networks

Motivation: Prediction of node and graph labels are prominent network science tasks. Data analyzed in these tasks are sometimes related: entities represented by nodes in a higher-level (higher scale) network can themselves be modeled as networks at a lower level. We argue that systems involving such entities should be integrated with a 'network of networks' (NoNs) representation. Then, we ask whether entity label prediction using multi-level NoN data via our proposed approaches is more accurate than using each of single-level node and graph data alone, i.e. than traditional node label prediction on the higher-level network and graph label prediction on the lower-level networks. To obtain data, we develop the first synthetic NoN generator and construct a real biological NoN. We evaluate accuracy of considered approaches when predicting artificial labels from the synthetic NoNs and proteins' functions from the biological NoN. Results: For the synthetic NoNs, our NoN approaches outperform or are as good as node- and network-level ones depending on the NoN properties. For the biological NoN, our NoN approaches outperform the single-level approaches for just under half of the protein functions, and for 30% of the functions, only our NoN approaches make meaningful predictions, while node- and network-level ones achieve random accuracy. So, NoN-based data integration is important.

Automated summary

In this study, the prediction of node and graph labels in network science tasks is explored. The integration of a "network of networks" (NoNs) representation is proposed. Experimental results using synthetic and biological NoNs show that our NoN approaches outperform other methods in accuracy, indicating the importance of data integration through NoNs for entity label prediction.