4.4 Review

Non-coding RNAs in photoaging-related mechanisms: a new paradigm in skin health

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pharmacology & Pharmacy

miR-1290 contributes to oncogenesis and angiogenesis via targeting of THBS1, DKK3 and, SCAI

Mohammad Hasan Soheilifar et al.

Summary: This study investigated the oncogenic and angiogenic potential of miR-1290 in colorectal cancer, revealing that miR-1290 enhances proliferation, migration, and angiogenesis by suppressing THBS1, DKK3, and SCAI. These findings suggest a novel function of miR-1290 contributing to tumorigenesis and angiogenesis in CRC.

BIOIMPACTS (2022)

Review Geriatrics & Gerontology

Biochemical, structural and physical changes in aging human skin, and their relationship

Seungman Park

Summary: Skin, as the largest organ of the human body, undergoes significant changes in its biochemical, structural, and physical properties during the aging process. This review provides an overview of these changes and explores the relationship among these properties. Furthermore, potential mechanisms are discussed based on previous findings.

BIOGERONTOLOGY (2022)

Article Multidisciplinary Sciences

Angioregulatory microRNAs in breast cancer: Molecular mechanistic basis and implications for therapeutic strategies

Mohammad Hasan Soheilifar et al.

Summary: This review aims to describe the current state of research on miRNA regulation in BC angiogenesis, as well as the association between miRNA dysregulation and anti-angiogenic response, and the potential clinical application of miRNA-based therapies.

JOURNAL OF ADVANCED RESEARCH (2022)

Article Dermatology

Predicting miRNA-lncRNA-mRNA network in ultraviolet A-induced human skin photoaging

Yao Lin et al.

Summary: The study revealed the interactions and regulatory network of miRNA-lncRNA-mRNAs in skin photoaging mechanisms, showing that UVA irradiation altered the gene expression of cellular processes and signaling pathways in fibroblasts. TNF signaling pathway, thyroid hormone signaling pathway, and lysosome were identified as major affected pathways after UVA exposure, indicating the critical role of miRNA-lncRNA-mRNA network in skin photoaging.

JOURNAL OF COSMETIC DERMATOLOGY (2021)

Review Dermatology

Cellular Senescence and the SenescenceAssociated Secretory Phenotype as Drivers of Skin Photoaging

Eleni Fitsiou et al.

Summary: This paper reviews how chronic UV exposure causes cells to prematurely enter senescence, leading to the accumulation of senescent cells in the skin and promoting impaired regenerative capacity, chronic inflammation, and tumorigenesis associated with photoaging. It concludes by highlighting the potential of senolytic drugs in delaying the onset and progression of age-related phenotypes in the skin.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

Review Dermatology

Environmentally-Induced (Extrinsic) Skin Aging: Exposomal Factors and Underlying Mechanisms

Jean Krutmann et al.

Summary: The skin, as a barrier organ, is an ideal model for studying environmentally-induced aging. This review explains how exposure to specific exposomal factors can lead to extrinsic skin aging, involving interactions between these factors and genetic modifications, ultimately causing macromolecular damage and changes in fibroblasts in the dermal compartment of the skin.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

Review Oncology

ROS and TGFβ: from pancreatic tumour growth to metastasis

Chao-Hui Chang et al.

Summary: The TGF beta signaling pathway and ROS have contrasting effects on early tumorigenesis and metastasis in pancreatic cancer, suggesting a potential synergistic role in promoting cancer malignancy.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Review Oncology

Possibility of inducing tumor cell senescence during therapy

Guohui Wang et al.

Summary: Treatment options for cancer include surgery, radiotherapy, and chemotherapy, but high-dose chemotherapy can have toxic side effects and lead to drug resistance. Cellular senescence is activated by various pathways and may inhibit the occurrence and development of tumors.

ONCOLOGY LETTERS (2021)

Review Cell Biology

Non-Coding RNAs Steering the Senescence-Related Progress, Properties, and Application of Mesenchymal Stem Cells

Jingyi Cai et al.

Summary: The desire to delay or even reverse aging has never diminished. Mesenchymal stem cells (MSCs) with unique abilities are highlighted, but their senescence can lead to age-related diseases or compromised therapeutic outcomes. Non-coding RNAs (ncRNAs) play a crucial role in regulating cellular fate, and a systematic exploration of ncRNAs steering MSCs during senescence is urgently needed. This review discusses the relationship between senescence and MSCs, the role of ncRNAs in MSC senescence, and the clinical applications of ncRNA-based therapies in MSC-related fields.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

An ex vivo model of human skin photoaging induced by UVA radiation compatible with summer exposure in Brazil

Bianca Oliveira Saguie et al.

Summary: This study developed a human ex vivo photoaging model induced by UVA exposure, showing that the model is capable of evaluating UVA-induced skin aging by demonstrating increased oxidative damage, inflammatory cells, collagenolytic and elastolytic MMPs expression, as well as decreased elastin expression.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2021)

Article Biotechnology & Applied Microbiology

Noncoding RNA therapeutics - challenges and potential solutions

Melanie Winkle et al.

Summary: In recent years, RNA-based therapies have gained FDA approval, but there are still challenges in targeting ncRNAs. Therapeutic targeting of noncoding RNAs has the potential to become a new approach for treating diseases such as cancer.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Dermatology

Identification and biological analysis of LncSPRY4-IT1-targeted functional proteins in photoaging skin

Wenyi Hou et al.

Summary: This study identified an increase in LncSPRY4-IT1 expression in photoaging fibroblasts and discovered 181 interacting proteins related to LncSPRY4-IT1, suggesting its crucial role in cellular processes, metabolic processes, and biological regulation in skin photoaging. The findings highlight the potential of LncSPRY4-IT1 as a novel target for intervention in the prevention and treatment of photoaging and related skin diseases.

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE (2021)

Article Medicine, Research & Experimental

Effects of long-term culture on the biological characteristics and RNA profiles of human bone-marrow-derived mesenchymal stem cells

Shan Wang et al.

Summary: Expansion of mesenchymal stem cells (MSCs) in vitro is a necessary process before application, and functional and genomic stability play crucial roles in stem cell therapies. This study investigated the expression and co-expression profiles of coding and non-coding RNAs in human bone marrow MSCs during in vitro aging, revealing significant differences in RNA levels among different passages. Key RNAs identified in bioinformatics analysis were validated, providing important considerations for therapeutic applications of MSCs.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Article Biochemistry & Molecular Biology

Protease-activated receptor 2 induces ROS-mediated inflammation through Akt-mediated NF-κB and FoxO6 modulation during skin photoaging

EunJin Bang et al.

Summary: This study shows that the PAR2 pathway plays a crucial role in skin photoaging, with inhibition of PAR2 effectively reducing inflammation and oxidative stress levels. PAR2 induces oxidative stress and inflammation through Akt-mediated phosphorylation of NF-kappa B and FoxO6, suggesting a key regulatory mechanism in ROS-mediated inflammatory response.

REDOX BIOLOGY (2021)

Article Oncology

Pharmacological Activation of Autophagy Restores Cellular Homeostasis in Ultraviolet-(B)-Induced Skin Photodamage

Sheikh Ahmad Umar et al.

Summary: The study investigates the protective role of autophagy in UV-B-exposed human dermal fibroblasts, showing that enhancing autophagy levels can regulate UV-B-induced cellular stress, alleviate oxidative stress, and have a positive impact on skin homeostasis.

FRONTIERS IN ONCOLOGY (2021)

Review Public, Environmental & Occupational Health

Targeting microRNA for improved skin health

Xi Li et al.

Summary: miRNAs play important regulatory roles in human skin, influencing cell proliferation, differentiation, immune regulation, and wound healing. Regulating miRNA expression shows promise as a novel therapy for skin diseases and cosmeceutical interventions to boost skin health.

HEALTH SCIENCE REPORTS (2021)

Article Biochemistry & Molecular Biology

Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells

Yuhui Liu et al.

Summary: Rhein, a component of Chinese herb rhubarb, has been shown to inhibit pancreatic cancer cell growth by inducing apoptosis and arresting the cell cycle. When combined with oxaliplatin, Rhein synergistically enhances apoptosis in pancreatic cancer cells through increased ROS levels and inactivation of the PI3K/AKT pathway, suggesting it may be an effective strategy to overcome drug resistance.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Dermatology

The Long Noncoding RNA UCA1 Negatively Regulates Melanogenesis in Melanocytes

Shiyao Pei et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

Article Biochemistry & Molecular Biology

MiRNA-27a decreases ultraviolet B irradiation-induced cell damage

YuanJing Zhang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Long non-coding RNAs in cutaneous biology and keratinocyte carcinomas

Minna Piipponen et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

Review Biochemistry & Molecular Biology

The Role of microRNAs in Organismal and Skin Aging

Marta Gerasymchuk et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Oncology

Ultraviolet Radiation and Melanomagenesis: From Mechanism to Immunotherapy

Xiaoying Sun et al.

FRONTIERS IN ONCOLOGY (2020)

Review Pharmacology & Pharmacy

Circular RNA: A novel potential biomarker for skin diseases

Xiaoting Wu et al.

PHARMACOLOGICAL RESEARCH (2020)

Review Biochemistry & Molecular Biology

Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases

In Soo Pyo et al.

MOLECULES (2020)

Review Medicine, Research & Experimental

Circular RNAs: Promising Molecular Biomarkers of Human Aging-Related Diseases via Functioning as an miRNA Sponge

Shuyue Ren et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

Review Medicine, Research & Experimental

The Ex Vivo Skin Model as an Alternative Tool for the Efficacy and Safety Evaluation of Topical Products

Samara Eberlin et al.

ATLA-ALTERNATIVES TO LABORATORY ANIMALS (2020)

Article Biochemistry & Molecular Biology

nc886, a non-coding RNA, inhibits UVB-induced MMP-9 and COX-2 expression via the PKR pathway in human keratinocytes

Kwang-Soo Lee et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Dermatology

Downregulation of TUG1 promotes melanogenesis and UVB-induced melanogenesis

Chuhan Fu et al.

EXPERIMENTAL DERMATOLOGY (2019)

Review Biochemistry & Molecular Biology

MicroRNA-Mediated Health-Promoting Effects of Phytochemicals

Hara Kang

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Medicine, Research & Experimental

Anti-photoaging effect of fermented agricultural by-products on ultraviolet B-irradiated hairless mouse skin

Sun-Il Choi et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019)

Review Pharmacology & Pharmacy

Environmental Stressors on Skin Aging. Mechanistic Insights

Concepcion Parrado et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Biochemistry & Molecular Biology

Circular RNAs: Biogenesis, Mechanism, and Function in Human Cancers

Xing Zhao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Physiology

WOUND HEALING: A CELLULAR PERSPECTIVE

Melanie Rodrigues et al.

PHYSIOLOGICAL REVIEWS (2019)

Review Cell Biology

Autophagy: Multiple Mechanisms to Protect Skin from Ultraviolet Radiation-Driven Photoaging

Mei Wang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Article Dermatology

Alternative test models for skin ageing research

Motoki Nakamura et al.

EXPERIMENTAL DERMATOLOGY (2018)

Article Medicine, Research & Experimental

Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells

Bingxin Zhang et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018)

Article Biochemistry & Molecular Biology

LncRNA RP11-670E13.6 Regulates Cell Cycle Progression in UVB Damaged Human Dermal Fibroblasts

Mengna Li et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2018)

Article Multidisciplinary Sciences

Identification of chronological and photoageing-associated microRNAs in human skin

Ankit Srivastava et al.

SCIENTIFIC REPORTS (2018)

Review Endocrinology & Metabolism

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

Jacob O'Brien et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Article Cell Biology

Extracellular RNA in aging

Douglas F. Dluzen et al.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2017)

Article Dermatology

Expression Profiles of Long Noncoding RNA in UVA-Induced Human Skin Fibroblasts

Yue Zheng et al.

SKIN PHARMACOLOGY AND PHYSIOLOGY (2017)

Article Dermatology

Introduction to skin aging

Desmond J. Tobin

JOURNAL OF TISSUE VIABILITY (2017)

Article Biochemistry & Molecular Biology

Circular RNA profiling reveals that circCOL3A1-859267 regulate type I collagen expression in photoaged human dermal fibroblasts

Yating Peng et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Dermatology

Analysis of lncRNAs expression in UVB-induced stress responses of melanocytes

Qinghai Zeng et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2016)

Review Biochemistry & Molecular Biology

Oxidative stress and autophagy: the clash between damage and metabolic needs

G. Filomeni et al.

CELL DEATH AND DIFFERENTIATION (2015)

Review Cell Biology

MicroRNAs in human skin ageing

Mara Mancini et al.

AGEING RESEARCH REVIEWS (2014)

Article Biotechnology & Applied Microbiology

Identification of microRNA-mRNA functional interactions in UVB-induced senescence of human diploid fibroblasts

Ruth Greussing et al.

BMC GENOMICS (2013)

Article Pharmacology & Pharmacy

MicroRNAs in Skin Response to UV Radiation

Deeba N. Syed et al.

CURRENT DRUG TARGETS (2013)

Article Biochemistry & Molecular Biology

Elevated miR-34c-5p Mediates Dermal Fibroblast Senescence by Ultraviolet Irradiation

Bing-rong Zhou et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2013)

Article Dermatology

MiR-23a regulates DNA damage repair and apoptosis in UVB-irradiated HaCaT cells

Ze Guo et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2013)

Article Medicine, Research & Experimental

Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts

In-Sook An et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2012)

Article Medicine, Research & Experimental

Baicalin modulates microRNA expression in UVB irradiated mouse skin

Yang Xu et al.

JOURNAL OF BIOMEDICAL RESEARCH (2012)

Article Medicine, Research & Experimental

UVB suppresses PTEN expression by upregulating miR-141 in HaCaT cells

Wei Li et al.

JOURNAL OF BIOMEDICAL RESEARCH (2011)

Review Pathology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

Jean -Philippe Coppe et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

Review Dermatology

The UV response of the skin: a review of the MAPK, NF kappa B and TNF alpha signal transduction pathways

Visalini Muthusamy et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2010)

Review Dermatology

Ultraviolet radiation and skin cancer

Deevya L. Narayanan et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2010)

Review Biochemistry & Molecular Biology

Molecular Mechanisms of Ultraviolet Radiation-Induced DNA Damage and Repair

Rajesh P. Rastogi et al.

JOURNAL OF NUCLEIC ACIDS (2010)

Article Biochemistry & Molecular Biology

MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response

Joris Pothof et al.

EMBO JOURNAL (2009)

Review Dermatology

The hairless mouse in skin research

Fernando Benavides et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2009)

Article Biochemistry & Molecular Biology

Differential Expression Profiles of microRNAs in NIH3T3 Cells in Response to UVB Irradiation

Ling Guo et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2009)