4.6 Review

Biosensors as diagnostic tools in clinical applications

期刊

出版社

ELSEVIER
DOI: 10.1016/j.bbcan.2022.188726

关键词

Cancer; Biosensors; Clinical diagnosis; Biomarker

资金

  1. European Regional Development Fund (ERDF) through NORTE 2020 (Regional Operational Programme North) [NORTE-01-0247-FEDER033533]
  2. LISBOA 2020 (Lisboa Operational Programme)
  3. BioISI project from Portuguese National Funding Agency for Science, Research and Technology (FCT) of Portugal [UID/MULTI/04046/2021]

向作者/读者索取更多资源

Nowadays, the development of new technological solutions in the medical field, especially biosensors, is a priority and a significant investment. Biomarkers combined with biosensors have the potential to revolutionize healthcare management, providing fast, cost-effective, reliable, and highly sensitive clinical diagnosis.
Nowadays, the development of new technological solutions in the medical field, in particular biosensors, is a priority and a ground for great scientific and financial investment. From glucose sensors to highly sensible and more precise molecular tools, this biotechnological field has gone through an exponential growth, but still the applications are very limited to the future potential foreseen in the medical area. In the last decade, the advances in the genomic field have permitted the identification of specific biomarkers related to certain diseases, becoming one of the main approaches used in clinical diagnosis. Biomarkers have different clinical values, in the sense that they may provide preventive, predictive, prognostic and therapeutic response related information, not being exclusively used for diagnostic purposes, but also be applied in health management and disease treatment. Therefore, biomarkers allied with biosensors have the potential to revolutionize the way healthcare is managed. The vast choice of bioreceptors such as nucleic acids, antibodies, antigens, enzymes and even whole cells, consents the diagnosis of diseases ranging from viral and bacterial infections to cancer and metabolism disorders. The major appeal of these sensing platforms is that it provides a fast, cost-effective, reliable, highly sensitive and easy way to obtain an earlier clinical diagnosis, which can significantly affect the survival rate or patient's prognosis. This review will explore some of the most recent devices available and its clinical applications.

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