相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance
Yumei Huang et al.
CELL DEATH AND DIFFERENTIATION (2021)
Adaptors as the regulators of HECT ubiquitin ligases
Sonia Shalini Shah et al.
CELL DEATH AND DIFFERENTIATION (2021)
The ubiquitin system: from cell signalling to disease biology and new therapeutic opportunities
Rune Busk Damgaard
CELL DEATH AND DIFFERENTIATION (2021)
Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor
Kim Ghilarducci et al.
FEBS JOURNAL (2021)
E2 enzymes in genome stability: pulling the strings behind the scenes
Hugh C. Osborne et al.
TRENDS IN CELL BIOLOGY (2021)
RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation
Tingting Li et al.
NATURE COMMUNICATIONS (2021)
Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib
Maobo Huang et al.
CANCER LETTERS (2021)
The Molecular Basis of Ubiquitin-Conjugating Enzymes (E2s) as a Potential Target for Cancer Therapy
Xiaodi Du et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
ZNRF1 Mediates Epidermal Growth Factor Receptor Ubiquitination to Control Receptor Lysosomal Trafficking and Degradation
Chia-Hsing Shen et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
A Novel Signature of CCNF-Associated E3 Ligases Collaborate and Counter Each Other in Breast Cancer
Shu-Chun Chang et al.
CANCERS (2021)
CDK1 in Breast Cancer: Implications for Theranostic Potential
Sepideh Izadi et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2020)
Recruitment of Ubiquitin within an E2 Chain Elongation Complex
Benjamin W. Cook et al.
BIOPHYSICAL JOURNAL (2020)
UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop
Xu Liu et al.
CELL DEATH & DISEASE (2020)
p27 as a Transcriptional Regulator: New Roles in Development and Cancer
Seyedeh Fatemeh Razavipour et al.
CANCER RESEARCH (2020)
ITCH as a potential therapeutic target in human cancers
Qing Yin et al.
SEMINARS IN CANCER BIOLOGY (2020)
Inhibiting ubiquitin conjugating enzyme E2 N by microRNA-590-3p reduced cell growth of cervical carcinoma
Ting-Ting Song et al.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2020)
Human FBXL8 Is a Novel E3 Ligase Which Promotes BRCA Metastasis by Stimulating Pro-Tumorigenic Cytokines and Inhibiting Tumor Suppressors
Shu-Chun Chang et al.
CANCERS (2020)
UBE2O Promotes Progression and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma
Xiyu Chen et al.
ONCOTARGETS AND THERAPY (2020)
UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation
Jingyuan Sun et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)
The role of ubiquitination in tumorigenesis and targeted drug discovery
Lu Deng et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)
Role of protein arginine methyltransferase 5 in human cancers
Wendi Xiao et al.
BIOMEDICINE & PHARMACOTHERAPY (2019)
Structural basis of generic versus specific E2-RING E3 interactions in protein ubiquitination
Mehmet Gundogdu et al.
PROTEIN SCIENCE (2019)
CDK4 Regulates Lysosomal Function and mTORC1 Activation to Promote Cancer Cell Survival
Laia Martinez-Carreres et al.
CANCER RESEARCH (2019)
The ubiquitin ligase adaptor SPOP in cancer
Matthew J. Cuneo et al.
FEBS JOURNAL (2019)
RAS: Striking at the Core of the Oncogenic Circuitry
Ryan C. Gimple et al.
FRONTIERS IN ONCOLOGY (2019)
High expression of UBE2T predicts poor prognosis and survival in multiple myeloma
Weilong Zhang et al.
CANCER GENE THERAPY (2019)
PRL-3 Promotes Ubiquitination and Degradation of AURKA and Colorectal Cancer Progression via Dephosphorylation of FZR1
Cheng Zhang et al.
CANCER RESEARCH (2019)
Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients
Jean M. Mulcahy Levy et al.
CELL DEATH AND DIFFERENTIATION (2019)
Expression and the potential functions of TRIM32 in lung cancer tumorigenesis
Hongmei Yin et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2019)
MDM2 antagonist-loaded targeted micelles in combination with doxorubicin: effective synergism against human glioblastoma via p53 re-activation
C. Sarisozen et al.
JOURNAL OF DRUG TARGETING (2019)
HECT-Type E3 Ubiquitin Ligases in Cancer
Francesca Bernassola et al.
TRENDS IN BIOCHEMICAL SCIENCES (2019)
A High-Throughput Assay for Monitoring Ubiquitination in Real Time
Tyler G. Franklin et al.
FRONTIERS IN CHEMISTRY (2019)
Protein neddylation and its alterations in human cancers for targeted therapy
Lisha Zhou et al.
CELLULAR SIGNALLING (2018)
Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1
Suping Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
MicroRNA-508 suppresses epithelial-mesenchymal transition, migration, and invasion of ovarian cancer cells through the MAPK1/ERK signaling pathway
Lan Hong et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2018)
A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment
Marc L. Hyer et al.
NATURE MEDICINE (2018)
ATR/CHK1 inhibitors and cancer therapy
Zhaojun Qiu et al.
RADIOTHERAPY AND ONCOLOGY (2018)
VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma
Jing Zhang et al.
SCIENCE (2018)
UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins
Doris Hellerschmied et al.
NATURE COMMUNICATIONS (2018)
Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer
Karan Bhuripanyo et al.
SCIENCE ADVANCES (2018)
Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4(CRBN) activity
Quinlan L. Sievers et al.
BLOOD (2018)
UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling
Anushka Dikshit et al.
CANCER RESEARCH (2018)
Multi-tiered pairing selectivity between E2 ubiquitin-conjugating enzymes and E3 ligases
Ilona Turek et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Crystal structure of the Ube2K/E2-25K and K48-linked di-ubiquitin complex provides structural insight into the mechanism of K48-specific ubiquitin chain synthesis
Jung-Gyu Lee et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)
Ubiquitin ligases in oncogenic transformation and cancer therapy
Daniela Senft et al.
NATURE REVIEWS CANCER (2018)
An E2-guided E3 Screen Identifies the RNF17-UBE2U Pair as Regulator of the Radiosensitivity, Immunodeficiency, Dysmorphic Features, and Learning Difficulties (RIDDLE) Syndrome Protein RNF168
Yingying Guo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer
Veronica Tisato et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)
Gastrin Enhances Autophagy and Promotes Gastric Carcinoma Proliferation via Inducing AMPK alpha
Zhuang Kun et al.
ONCOLOGY RESEARCH (2017)
TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis
Ling Hao et al.
ONCOLOGY LETTERS (2017)
Rnf2 knockdown reduces cell viability and promotes cell cycle arrest in gastric cancer cells
Jinufang Zhang et al.
ONCOLOGY LETTERS (2017)
Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer
Yiyang Wang et al.
NATURE COMMUNICATIONS (2017)
Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI
Lingmin Yuan et al.
NATURE COMMUNICATIONS (2017)
The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation
Chih-Yuan Lee et al.
NATURE COMMUNICATIONS (2017)
The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function
Lixin Wan et al.
CANCER DISCOVERY (2017)
TRIM47 overexpression is a poor prognostic factor and contributes to carcinogenesis in non-small cell lung carcinoma
Yudong Han et al.
ONCOTARGET (2017)
Stromal cell extracellular vesicular cargo mediated regulation of breast cancer cell metastasis via ubiquitin conjugating enzyme E2 N pathway
Krishna C. Vallabhaneni et al.
ONCOTARGET (2017)
MicroRNA miR-147b promotes tumor growth via targeting UBE2N in hepatocellular carcinoma
En Zhang et al.
ONCOTARGET (2017)
TRIM22 confers poor prognosis and promotes epithelial-mesenchymal transition through regulation of AKT/GSK3β/β-catenin signaling in non-small cell lung cancer
Li Liu et al.
ONCOTARGET (2017)
UBE2T knockdown inhibits gastric cancer progression
Changjiang Luo et al.
ONCOTARGET (2017)
UBE2T promotes hepatocellular carcinoma cell growth via ubiquitination of p53
Li-ping Liu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
mTORC1 signaling and the metabolic control of cell growth
Issam Ben-Sahra et al.
CURRENT OPINION IN CELL BIOLOGY (2017)
A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy
Isabelle K. Vila et al.
CANCER CELL (2017)
Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance
Federico Pietrocola et al.
CANCER CELL (2016)
Rapid Diminution in the Level and Activity of DNA-Dependent Protein Kinase in Cancer Cells by a Reactive Nitro-Benzoxadiazole Compound
Viviane A. O. Silva et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)
Inhibition of WWP2 suppresses proliferation, and induces G1 cell cycle arrest and apoptosis in liver cancer cells
Sheng-Qian Xu et al.
MOLECULAR MEDICINE REPORTS (2016)
Knockdown of UBE2T Inhibits Osteosarcoma Cell Proliferation, Migration, and Invasion by Suppressing the PI3K/Akt Signaling Pathway
Yu Wang et al.
ONCOLOGY RESEARCH (2016)
UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells
Yan Qing Gong et al.
ONCOLOGY LETTERS (2016)
UBE2T promotes nasopharyngeal carcinoma cell proliferation, invasion, and metastasis by activating the AKT/GSK3β/β-catenin pathway
Wei Hu et al.
ONCOTARGET (2016)
Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells
Huiyin Lan et al.
SCIENTIFIC REPORTS (2016)
Non-degradative Ubiquitination of Protein Kinases
K. Aurelia Ball et al.
PLOS COMPUTATIONAL BIOLOGY (2016)
Recent insights into cell death and autophagy
Brent E. Fitzwalter et al.
FEBS JOURNAL (2015)
β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis
Satdarshan Pal Monga
GASTROENTEROLOGY (2015)
Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B
Jeffrey Hannah et al.
GENE (2015)
NEDD4-2 (NEDD4L): The ubiquitin ligase for multiple membrane proteins
Pranay Goel et al.
GENE (2015)
Regulation of mTORC1 by PI3K signaling
Christian C. Dibble et al.
TRENDS IN CELL BIOLOGY (2015)
BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase
Asad M. Taherbhoy et al.
NATURE COMMUNICATIONS (2015)
The Four Faces of Autophagy: Implications for Cancer Therapy
David A. Gewirtz
CANCER RESEARCH (2014)
Ubiquitination by SAG regulates macrophage survival/death and immune response during infection
S. C. Chang et al.
CELL DEATH AND DIFFERENTIATION (2014)
Autophagy Is a Survival Mechanism of Acute Myelogenous Leukemia Precursors during Dual mTORC2/mTORC1 Targeting
Jessica K. Altman et al.
CLINICAL CANCER RESEARCH (2014)
Autodeubiquitination Protects the Tumor Suppressor BAP1 from Cytoplasmic Sequestration Mediated by the Atypical Ubiquitin Ligase UBE2O
Nazar Mashtalir et al.
MOLECULAR CELL (2014)
Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome
Robert K. McGinty et al.
NATURE (2014)
Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade
Xuefeng Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Regulation of mTORC1 by amino acids
Liron Bar-Peled et al.
TRENDS IN CELL BIOLOGY (2014)
A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity
Brian C. Grabiner et al.
CANCER DISCOVERY (2014)
Versatile Roles of K63-Linked Ubiquitin Chains in Trafficking
Zoi Erpapazoglou et al.
Cells (2014)
High cereblon expression is associated with better survival in patients with newly diagnosed multiple myeloma treated with thalidomide maintenance
Annemiek Broyl et al.
BLOOD (2013)
UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination
Xiaofei Zhang et al.
CELL RESEARCH (2013)
Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6
Xiaofei Zhang et al.
EMBO JOURNAL (2013)
mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
Francesca Nazio et al.
NATURE CELL BIOLOGY (2013)
E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1
Reuven Wiener et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
Atlas of Genetics and Cytogenetics in Oncology and Haematology in 2013
Jean-Loup Huret et al.
NUCLEIC ACIDS RESEARCH (2013)
Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic syndrome with chromosome 5q deletion
S. Wei et al.
ONCOGENE (2013)
RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumor development
Wen-jing Su et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
The Endoplasmic Reticulum Acts as a Platform for Ubiquitylated Components of Nuclear Factor κB Signaling
Catherine Alexia et al.
SCIENCE SIGNALING (2013)
Linear ubiquitination: a newly discovered regulator of cell signalling
Eva Rieser et al.
TRENDS IN BIOCHEMICAL SCIENCES (2013)
Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis
B. B. Chen et al.
CELL DEATH & DISEASE (2013)
An open-label, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib
Ravi Vij et al.
BRITISH JOURNAL OF HAEMATOLOGY (2012)
mTOR Signaling in Growth Control and Disease
Mathieu Laplante et al.
CELL (2012)
Orthogonal Ubiquitin Transfer through Engineered E1-E2 Cascades for Protein Ubiquitination
Bo Zhao et al.
CHEMISTRY & BIOLOGY (2012)
ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase
Gerta Hoxhaj et al.
JOURNAL OF CELL SCIENCE (2012)
HECT and RING finger families of E3 ubiquitin ligases at a glance
Meredith B. Metzger et al.
JOURNAL OF CELL SCIENCE (2012)
Human Proteome-scale Structural Modeling of E2-E3 Interactions Exploiting Interface Motifs
Gozde Kar et al.
JOURNAL OF PROTEOME RESEARCH (2012)
A Human Ubiquitin Conjugating Enzyme (E2)-HECT E3 Ligase Structure-function Screen
Yi Sheng et al.
MOLECULAR & CELLULAR PROTEOMICS (2012)
F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest
B. B. Chen et al.
ONCOGENE (2012)
Functional interactions between ubiquitin E2 enzymes and TRIM proteins
Luisa M. Napolitano et al.
BIOCHEMICAL JOURNAL (2011)
Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex
Matthew L. Bentley et al.
EMBO JOURNAL (2011)
Assembly of different length of polyubiquitins on the catalytic cysteine of E2 enzymes without E3 ligase; a novel application of non-reduced/reduced 2-dimensional electrophoresis
Dong Yeon Shin et al.
FEBS LETTERS (2011)
Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers
Ruiying Zhao et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
Woong Kim et al.
MOLECULAR CELL (2011)
Discovery of Mdm2-MdmX E3 Ligase Inhibitors Using a Cell-Based Ubiquitination Assay
Ariel G. Herman et al.
CANCER DISCOVERY (2011)
Not a peripheral issue: secretion in plant-microbe interactions
Pawel Bednarek et al.
CURRENT OPINION IN PLANT BIOLOGY (2010)
The RasGAP Proteins Ira2 and Neurofibromin Are Negatively Regulated by Gpb1 in Yeast and ETEA in Humans
Vernon T. Phan et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
TRAF6 and A20 Regulate Lysine 63-Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy
Chong-Shan Shi et al.
SCIENCE SIGNALING (2010)
Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation
Ping Xu et al.
CELL (2009)
Control of autophagy by oncogenes and tumor suppressor genes
M. C. Maiuri et al.
CELL DEATH AND DIFFERENTIATION (2009)
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network
Gabriel Markson et al.
GENOME RESEARCH (2009)
Insights into Ubiauitin Transfer Cascades from a Structure of a UbcH5B∼Ubiauitin-HECTNEDD4L Complex
Hari B. Kamadurai et al.
MOLECULAR CELL (2009)
A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system
Sjoerd J. L. van Wijk et al.
MOLECULAR SYSTEMS BIOLOGY (2009)
Targeting the ubiquitin system in cancer therapy
Daniela Hoeller et al.
NATURE (2009)
The molecular programme of tumour reversion: the steps beyond malignant transformation
Adam Telerman et al.
NATURE REVIEWS CANCER (2009)
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression
Adam S. Adler et al.
CANCER RESEARCH (2008)
Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2
Jirouta Kitagaki et al.
MOLECULAR CANCER THERAPEUTICS (2008)
Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation
Kazunori Sato et al.
CANCER RESEARCH (2007)
The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy
Philipp Christoph Janiesch et al.
NATURE CELL BIOLOGY (2007)
Mapping cellular routes of Ras - A ubiquitin trail
Natalia Jura et al.
CELL CYCLE (2006)
Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma
Richard I. Fisher et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription
G. Sebastiaan Winkler et al.
EMBO JOURNAL (2006)
Mammalian E4 is required for cardiac development and maintenance of the nervous system
C Kaneko-Oshikawa et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
YL Yang et al.
CANCER CELL (2005)
Role of histone H2A ubiquitination in polycomb silencing
HB Wang et al.
NATURE (2004)
Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo
MK Saville et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
A phase 2 study of bortezomib in relapsed, refractory myeloma
PG Richardson et al.
NEW ENGLAND JOURNAL OF MEDICINE (2003)
Structure of the yeast nucleosome core particle reveals fundamental changes in internucleosome interactions
CL White et al.
EMBO JOURNAL (2001)
Molecular insights into polyubiquitin chain assembly: Crystal structure of the Mms2/Ubc13 heterodimer
AP VanDemark et al.
CELL (2001)
The tripartite motif family identifies cell compartments
A Reymond et al.
EMBO JOURNAL (2001)
Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k
T Yokota et al.
GENE (2001)
Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases
N Zheng et al.
CELL (2000)
分享论文
