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ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis
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FGF23-Klotho signaling axis in the kidney
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ADAM10-Dependent Signaling Through Notchl and Notch4 Controls Development of Organ-Specific Vascular Beds
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JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2016)
Phosphatidylserine exposure is required for ADAM17 sheddase function
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NATURE COMMUNICATIONS (2016)
The Emerging Role of Tetraspanins in the Proteolytic Processing of the Amyloid Precursor Protein
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ADAM17 substrate release in proximal tubule drives kidney fibrosis
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A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung metastasis formation
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CELLULAR AND MOLECULAR LIFE SCIENCES (2015)
The Cytoplasmic Domain of A Disintegrin and Metalloproteinase 10 (ADAM10) Regulates Its Constitutive Activity but Is Dispensable for Stimulated ADAM10-dependent Shedding
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JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
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Polycystin-1 and Gα12 regulate the cleavage of E-cadherin in kidney epithelial cells
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PHYSIOLOGICAL GENOMICS (2015)
ADAM10 Is the Major Sheddase Responsible for the Release of Membrane-associated Meprin A
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mTOR controls kidney epithelia in health and disease
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NEPHROLOGY DIALYSIS TRANSPLANTATION (2014)
ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease
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Insulin treatment attenuates renal ADAM17 and ACE2 shedding in diabetic Akita mice
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ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis
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BRITISH JOURNAL OF PHARMACOLOGY (2013)
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin beta and ADAM10
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Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease
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ADAM17 up-regulation in renal transplant dysfunction and non-transplant-related renal fibrosis
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Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures
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Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function
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Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10
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ADAMs 10 and 17 Represent Differentially Regulated Components of a General Shedding Machinery for Membrane Proteins Such as Transforming Growth Factor α, L-Selectin, and Tumor Necrosis Factor α
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Regulation of Renal Outer Medullary Potassium Channel and Renal K+ Excretion by Klotho
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The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
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The β-glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6
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NEPHROLOGY DIALYSIS TRANSPLANTATION (2008)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events
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Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
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NATURE MEDICINE (2007)
ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice
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KIDNEY INTERNATIONAL (2007)
Synapse-associated protein-97 mediates α-secretase ADAM10 trafficking and promotes its activity
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JOURNAL OF NEUROSCIENCE (2007)
Klotho converts canonical FGF receptor into a specific receptor for FGF23
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NATURE (2006)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The β-glucuronidase klotho hydrolyzes and activates the TRPV5 channel
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SCIENCE (2005)
Tumor necrosis factor-α convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)
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ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and β-catenin nuclear signalling
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EMBO JOURNAL (2005)
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
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JOURNAL OF CELL BIOLOGY (2004)
The transmembrane CXC-chemokine ligand 16 is induced by IFN-γ and TNF-α and shed by the activity of the disintegrin-like metalloproteinase ADAM10
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PACSIN3 binds ADAM12/meltrin α and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
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KIDNEY INTERNATIONAL (2003)
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
ADAMs: modulators of cell-cell and cell-matrix interactions
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The ADAMs family of metalloproteases: multidomain proteins with multiple functions
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GENES & DEVELOPMENT (2003)
Vascular endothelial growth factor: a new player in the pathogenesis of renal fibrosis
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CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2003)
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for α-secretase activity in fibroblasts
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HUMAN MOLECULAR GENETICS (2002)
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KIDNEY INTERNATIONAL (2002)
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Kuzbanian-mediated cleavage of Drosophila Notch
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Meprin, a brush-border enzyme, plays an important role in hypoxic/ischemic acute renal tubular injury in rats
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Changes in sodium or glucose filtration rate modulate expression of glucose transporters in renal proximal tubular cells of rat
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JOURNAL OF MEMBRANE BIOLOGY (2001)
Renal fibrosis:: an update
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CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2001)
Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
MS Brown et al.
CELL (2000)
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