期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1868, 期 4, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2022.166352
关键词
Endothelial cells; Senescence; Cancer therapy; Anthracyclines; Radiation; Cardio-oncology
资金
- National Heart, Lung, and Blood Institute [R01HL151740]
- National Institutes of Health's National Center for Advancing Translational Sciences [UL1TR002494]
- Bighley Graduate Fellowship from the College of Pharmacy, University of Minnesota
Therapy-induced senescence is a fundamental mechanism contributing to adverse health complications in cancer survivors. This mini-review focuses on the mechanisms of endothelial cell senescence and discusses novel senotherapeutic approaches.
Cancer survivorship has remarkably improved over the past decades; nevertheless, cancer survivors are burdened with multiple health complications primarily caused by their cancer therapy. Therapy-induced senescence is recognized as a fundamental mechanism contributing to adverse health complications in cancer survivors. In this mini-review, we will discuss the recent literature describing the mechanisms of cancer therapy-induced senescence. We will focus on endothelial cell senescence since it has been shown to be a key player in numerous cardiovascular complications. We will also discuss novel senotherapeutic approaches that have the potential to combat therapy-induced endothelial cell senescence.
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