4.7 Review

Obesity I: Overview and molecular and biochemical mechanisms

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Review Neurosciences

The role of extracellular vesicles in skeletal muscle and systematic adaptation to exercise

Ivan J. Vechetti et al.

Summary: Regular exercise plays a crucial role in reducing the risk of certain diseases. Skeletal muscle-specific cytokines and extracellular vesicles released during exercise may contribute to the positive effects on metabolism. Research on the potential role of EVs in muscle and systemic adaptation to exercise has generated interest in various fields.

JOURNAL OF PHYSIOLOGY-LONDON (2021)

Review Immunology

Gut microbiome, liver immunology, and liver diseases

Rui Wang et al.

Summary: The delicate interaction between the gut microbiota and liver is crucial in preventing accidental immune activation against harmless antigens, also aiding in understanding and treating various liver diseases.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Review Biochemistry & Molecular Biology

Mechanisms of Insulin Resistance at the Crossroad of Obesity with Associated Metabolic Abnormalities and Cognitive Dysfunction

Thomas M. Barber et al.

Summary: Obesity leads to the development of insulin resistance, which in turn causes various metabolic consequences. Insulin resistance is associated with multiple complex pathogenic pathways, including chronic inflammation and mitochondrial dysfunction. Lifestyle optimization, such as regular physical activity, improved diet, and sufficient sleep, can effectively reverse insulin resistance without medication intervention.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Endocrinology & Metabolism

The importance of 24-h metabolism in obesity-related metabolic disorders: opportunities for timed interventions

Charlotte Andriessen et al.

Summary: The body's various metabolic processes are influenced by the biological clock, and circadian rhythms are affected by environmental and behavioral time cues. These rhythms are disrupted in adults with obesity-related metabolic disturbances. Adjusting the timing of eating and exercise can help reinforce circadian rhythms and improve metabolic health.

INTERNATIONAL JOURNAL OF OBESITY (2021)

Review Environmental Sciences

Effects of Combined Exercise and Low Carbohydrate Ketogenic Diet Interventions on Waist Circumference and Triglycerides in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis

Hyun Suk Lee et al.

Summary: Participation in CELCKD interventions by overweight and obese individuals resulted in decreased waist circumference and triglycerides, with no statistically significant differences in cardiovascular health, body composition, fasting glucose, and lipid profiles. No adverse side effects were reported. Longer term intervention studies with consistent control groups may be necessary.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2021 Update A Report From the American Heart Association

Salim S. Virani et al.

Summary: The American Heart Association, in partnership with the National Institutes of Health, publishes annual statistics on heart disease, stroke, and cardiovascular risk factors, including the impact of health behaviors and factors on cardiovascular health. The Statistical Update covers a range of clinical heart and circulatory conditions, providing data on quality of care, procedures, and economic costs. It serves as a critical resource for various stakeholders seeking the best available data on these factors and conditions.

CIRCULATION (2021)

Article Cell & Tissue Engineering

Unraveling the Developmental Roadmap toward Human Brown Adipose Tissue

Stefania Carobbio et al.

Summary: The research team has developed a new chemically defined protocol for differentiating human pluripotent stem cells into brown adipocytes, overcoming limitations in BAT research. The obtained brown adipocytes express markers and respond to stimuli.

STEM CELL REPORTS (2021)

Review Endocrinology & Metabolism

Beige Adipose Tissue Identification and Marker Specificity-Overview

Anna-Claire Pilkington et al.

Summary: Adipose tissue is classified based on its characteristics, but differentiating beige adipose tissue (BeAT) remains a challenge. Recent research focuses on identifying different types of adipose tissue through transcript markers to advance understanding of their biology. The development of concrete strategies to distinguish types of adipose tissue may be crucial for improving metabolic health and preventing excessive weight gain.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Medicine, Research & Experimental

Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD

Hui Li et al.

Summary: Exercise plays a significant role in reducing liver steatosis and insulin resistance in NAFLD by activating the AMPK/SIRT1 signaling pathway and enhancing lipophagy.

LIFE SCIENCES (2021)

Review Biochemistry & Molecular Biology

Modulations of obesity-related microRNAs after exercise intervention: a systematic review and bioinformatics analysis

Naeim Ehtesham et al.

Summary: This study investigates the impact of exercise on miRNA expression in individuals with obesity, highlighting the role of miRNAs in obesity and exercise adaptation mechanisms. Further research is needed to fully understand the underlying molecular pathways.

MOLECULAR BIOLOGY REPORTS (2021)

Article Pediatrics

Association between ectopic pancreatic and hepatic fat and metabolic risk factors in children with non-alcoholic fatty liver disease

Eun Hye Lee et al.

Summary: In children with NAFLD, hepatic fat fraction (HFF) was associated with total body fat% and GGT, while pancreatic fat fraction (PFF) was associated with diastolic blood pressure, GGT, and fasting plasma glucose. This suggests that the pathophysiology of ectopic fat accumulation varies across organs in children with NAFLD.

PEDIATRIC OBESITY (2021)

Review Endocrinology & Metabolism

Dopaminergic Control of the Feeding Circuit

Ja-Hyun Baik

Summary: Dopamine plays a critical role in the control of feeding behavior by linking energy state-associated signals to reward-related behaviors, through both the reward-related circuit and the homeostatic hypothalamic system.

ENDOCRINOLOGY AND METABOLISM (2021)

Article Nutrition & Dietetics

The carbohydrate-insulin model: a physiological perspective on the obesity pandemic

David S. Ludwig et al.

Summary: The obesity pandemic may be not only caused by excessive consumption of high-energy foods and lack of exercise, but also related to biological mechanisms. The carbohydrate-insulin model proposes a new cognitive framework, emphasizing hormonal responses to a high glycemic load diet.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2021)

Article Endocrinology & Metabolism

Are people with metabolically healthy obesity really healthy? A prospective cohort study of 381,363 UK Biobank participants

Ziyi Zhou et al.

Summary: The study found that individuals with metabolically healthy obesity (MHO) had higher rates of heart failure and respiratory diseases, but not necessarily atherosclerotic cardiovascular diseases. Compared to metabolically healthy individuals without obesity, those with MHO had higher risks of diabetes, cardiovascular diseases, heart failure, respiratory diseases, and all-cause mortality.

DIABETOLOGIA (2021)

Article Medicine, General & Internal

Trends in Prevalence of Type 1 and Type 2 Diabetes in Children and Adolescents in the US, 2001-2017

Jean M. Lawrence et al.

Summary: The prevalence of type 1 and type 2 diabetes among children and adolescents in the US increased significantly from 2001 to 2017, with particular attention on the rise in type 1 diabetes among those younger than 19 years old.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Medicine, General & Internal

Long-Term Complications in Youth-Onset Type 2 Diabetes

Petter Bjornstad et al.

Summary: Youth-onset type 2 diabetes patients are at increasing risk of complications over time, with most developing complications by young adulthood. Complications were more common among participants of minority race and ethnic group and those with hyperglycemia, hypertension, and dyslipidemia.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Medicine, Research & Experimental

Interconnections between circadian clocks and metabolism

Dongyin Guan et al.

Summary: Circadian rhythms evolved through adaptation to daily light/dark changes in the environment and are regulated by the core circadian clock genes, which play important roles in metabolism. Environmental stimuli such as artificial light, unbalanced diet, mistimed eating, and exercise can disrupt circadian physiological processes and lead to metabolic disorders.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Medicine, Research & Experimental

Differential roles of FOXO transcription factors on insulin action in brown and white adipose tissue

Erica P. Homan et al.

Summary: The research found that FOXO transcription factors play different roles in the action of insulin/IGF-1 in different adipose tissue, with the most significant effect in BAT. While the loss of FOXOs in fat can partially rescue subcutaneous WAT and hepatosteatosis, it cannot rescue systemic insulin resistance and may lead to more severe hyperinsulinemia.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Review Biochemistry & Molecular Biology

Adipose tissue plasticity and the pleiotropic roles of BMP signaling

Shuwen Qian et al.

Summary: Adipose tissues, including different types such as white, beige, and brown adipose tissue, are highly dynamic and undergo profound changes during development and regeneration. Bone morphogenetic proteins (BMPs), with their pleiotropic functions, play a crucial role in regulating the differentiation of adipocytes and macrophages in adipose tissues.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Endocrinology & Metabolism

White adipose tissue mitochondrial metabolism in health and in obesity

Sini Heinonen et al.

OBESITY REVIEWS (2020)

Article Endocrinology & Metabolism

Adenovirus 36 seropositivity is related to obesity risk, glycemic control, and leptin levels in Chilean subjects

Jorge Sapunar et al.

INTERNATIONAL JOURNAL OF OBESITY (2020)

Review Endocrinology & Metabolism

Metabolically Healthy Obesity

Matthias Blueher

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Circadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease

Anand R. Saran et al.

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Obesity and COVID-19: immune and metabolic derangement as a possible link to adverse clinical outcomes

Emmanouil Korakas et al.

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Sex-Specific Regulation of Inflammation and Metabolic Syndrome in Obesity

Rob ter Horst et al.

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Maternal exercise and its beneficial effects on glucose metabolism in offspring

Jia Zheng et al.

CHINESE MEDICAL JOURNAL (2020)

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Exercise-Released Myokines in the Control of Energy Metabolism

Claire Laurens et al.

FRONTIERS IN PHYSIOLOGY (2020)

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The Exercise Training Modulatory Effects on the Obesity-Induced Immunometabolic Dysfunctions

Nakisa Soltani et al.

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Article Environmental Sciences

Early -Life Environmental Exposures and Childhood Obesity: An Exposome-Wide Approach

Martine Vrijheid et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2020)

Article Gastroenterology & Hepatology

Progression of Fatty Liver Disease in Children Receiving Standard of Care Lifestyle Advice

Stavra A. Xanthakos et al.

GASTROENTEROLOGY (2020)

Article Biochemistry & Molecular Biology

CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling

Yasuo Oguri et al.

Review Endocrinology & Metabolism

The emerging role of lactate as a mediator of exercise-induced appetite suppression

Seth F. McCarthy et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2020)

Review Endocrinology & Metabolism

Diet and exercise in the prevention and treatment of type 2 diabetes mellitus

Faidon Magkos et al.

NATURE REVIEWS ENDOCRINOLOGY (2020)

Review Pediatrics

Neonatal Diabetes Mellitus

Jacques Beltrand et al.

FRONTIERS IN PEDIATRICS (2020)

Review Biochemistry & Molecular Biology

Endurance Exercise Mitigates Immunometabolic Adipose Tissue Disturbances in Cancer and Obesity

Jose Cesar Rosa-Neto et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

ER-Mitochondria Contacts and Insulin Resistance Modulation through Exercise Intervention

Yi Sun et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Endocrinology & Metabolism

Role of exercise on insulin sensitivity and beta-cell function: is exercise sufficient for the prevention of youth-onset type 2 diabetes?

Joon Young Kim et al.

ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2020)

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The intestinal microbiota fuelling metabolic inflammation

Herbert Tilg et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Muscle and adipose tissue insulin resistance: malady without mechanism?

Daniel J. Fazakerley et al.

JOURNAL OF LIPID RESEARCH (2019)

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Inducible Loss of the Aryl Hydrocarbon Receptor Activates Perigonadal White Fat Respiration and Brown Fat Thermogenesis via Fibroblast Growth Factor 21

Nathaniel G. Girer et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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The circadian clock and liver function in health and disease

Atish Mukherji et al.

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Obesity: global epidemiology and pathogenesis

Matthias Blueher

NATURE REVIEWS ENDOCRINOLOGY (2019)

Editorial Material Endocrinology & Metabolism

The obesity transition: stages of the global epidemic

Lindsay M. Jaacks et al.

LANCET DIABETES & ENDOCRINOLOGY (2019)

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Extracellular Vesicles: Delivery Vehicles of Myokines

Eleonora Trovato et al.

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Childhood obesity: Aetiology, comorbidities, and treatment

William Javier Morales Camacho et al.

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Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication

Jan-Bernd Funcke et al.

JOURNAL OF LIPID RESEARCH (2019)

Article Cell Biology

The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

Anthony T. Virtue et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Metabolically healthy obesity: facts and fantasies

Gordon Smith et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Review Medicine, Research & Experimental

Contribution of adipogenesis to healthy adipose tissue expansion in obesity

Lavanya Vishvanath et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Gut Microbiota and Obesity: A Role for Probiotics

Ludovico Abenavoli et al.

NUTRIENTS (2019)

Review Immunology

The gut microbiome: Relationships with disease and opportunities for therapy

Juliana Durack et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Prevalence of Optimal Metabolic Health in American Adults: National Health and Nutrition Examination Survey 2009-2016

Joana Araujo et al.

METABOLIC SYNDROME AND RELATED DISORDERS (2019)

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Thermal stress induces glycolytic beige fat formation via a myogenic state

Yong Chen et al.

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Obesity as a Disease: The Obesity Society 2018 Position Statement

Ania M. Jastreboff et al.

OBESITY (2019)

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Changes in Age Distribution of Obesity-Associated Cancers

Siran M. Koroukian et al.

JAMA NETWORK OPEN (2019)

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Effect of Circadian Rhythm on Metabolic Processes and the Regulation of Energy Balance

Yeliz Serin et al.

ANNALS OF NUTRITION AND METABOLISM (2019)

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TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

Peng Zhao et al.

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Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

Allison Agus et al.

CELL HOST & MICROBE (2018)

Review Cell Biology

Overlapping Brain Circuits for Homeostatic and Hedonic Feeding

Mark A. Rossi et al.

CELL METABOLISM (2018)

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Body mass index and the risk of infection - from underweight to obesity

J. Dobner et al.

CLINICAL MICROBIOLOGY AND INFECTION (2018)

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Epigenetics as a mechanism linking developmental exposures to long-term toxicity

R. Barouki et al.

ENVIRONMENT INTERNATIONAL (2018)

Article Pharmacology & Pharmacy

Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells

Meng Li et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

Article Gastroenterology & Hepatology

Human gut microbiome: hopes, threats and promises

Patrice D. Cani

Review Behavioral Sciences

Diverse actions of estradiol on anorexigenic and orexigenic hypothalamic arcuate neurons

Todd L. Stincic et al.

HORMONES AND BEHAVIOR (2018)

Review Biochemistry & Molecular Biology

Mecasermin in Insulin Receptor-Related Severe Insulin Resistance Syndromes: Case Report and Review of the Literature

Michaela Plamper et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Surgery

Epidemiology of Obesity and Associated Comorbidities

Ciro Andolfi et al.

JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES (2018)

Article Biochemistry & Molecular Biology

Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health

Ludivine Laurans et al.

NATURE MEDICINE (2018)

Review Endocrinology & Metabolism

Maternal Exercise Improves the Metabolic Health of Adult Offspring

Johan E. Harris et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2018)

Review Endocrinology & Metabolism

Pink Adipocytes

Saverio Cinti

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2018)

Editorial Material Medicine, General & Internal

Dietary carbohydrates: role of quality and quantity in chronic disease

David S. Ludwig et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

Editorial Material Medicine, General & Internal

Dietary carbohydrates: role of quality and quantity in chronic disease

David S. Ludwig et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

Review Endocrinology & Metabolism

Brown Adipose Tissue Energy Metabolism in Humans

Andre C. Carpentier et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Review Endocrinology & Metabolism

Links Between Obesity-Induced Brain Insulin Resistance, Brain Mitochondrial Dysfunction, and Dementia

Jirapas Sripetchwandee et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Review Endocrinology & Metabolism

Obesity and nonalcoholic fatty liver disease: current perspectives

Raiya Sarwar et al.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2018)

Review Biochemistry & Molecular Biology

Exercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and Obesity

Alex Cleber Improta Caria et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Neurosciences

Secular Trends in Dementia Prevalence and Incidence Worldwide: A Systematic Review

Blossom C. M. Stephan et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Review Multidisciplinary Sciences

Deciphering adipose tissue heterogeneity

Matthew D. Lynes et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2018)

Article Biochemistry & Molecular Biology

Lipedema: friend and foe

Yanira Sanchez-De la Torre et al.

HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION (2018)

Review Endocrinology & Metabolism

Glucocorticoid Signaling in Health and Disease: Insights From Tissue-Specific GR Knockout Mice

Shannon Whirledge et al.

ENDOCRINOLOGY (2018)

Review Medicine, General & Internal

Roles of the gut in the metabolic syndrome: an overview

L. Fandriks

JOURNAL OF INTERNAL MEDICINE (2017)

Review Endocrinology & Metabolism

Obesity Pathogenesis: An Endocrine Society Scientific Statement

Michael W. Schwartz et al.

ENDOCRINE REVIEWS (2017)

Review Medicine, Research & Experimental

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis

Clair Crewe et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Review Medicine, Research & Experimental

Inflammatory mechanisms linking obesity and metabolic disease

Alan R. Saltiel et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Review Endocrinology & Metabolism

Adapting to obesity with adipose tissue inflammation

Shannon M. Reilly et al.

NATURE REVIEWS ENDOCRINOLOGY (2017)

Review Behavioral Sciences

The impact of gut hormones on the neural circuit of appetite and satiety: A systematic review

Davide Zanchi et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2017)

Review Endocrinology & Metabolism

Making sense of metabolic obesity and hedonic obesity

Yi-Hao Yu

JOURNAL OF DIABETES (2017)

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Role of aryl hydrocarbon receptor in mesenchymal stromal cell activation: A minireview

Danilo Candido de Almeida et al.

WORLD JOURNAL OF STEM CELLS (2017)

Article Endocrinology & Metabolism

The Role of Brain in Energy Balance

Paulo Matafome et al.

OBESITY AND BRAIN FUNCTION (2017)

Article Pharmacology & Pharmacy

An appetite for life: brain regulation of hunger and satiety

Lora K. Heisler et al.

CURRENT OPINION IN PHARMACOLOGY (2017)

Review Biochemistry & Molecular Biology

Circadian control of metabolism and pathological consequences of clock perturbations

Alicia Mayeuf-Louchart et al.

BIOCHIMIE (2017)

Review Endocrinology & Metabolism

The glucocorticoid receptor: cause of or cure for obesity?

Kezia John et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2016)

Article Pharmacology & Pharmacy

Obesity and cancer: inflammation bridges the two

Ryan Kolb et al.

CURRENT OPINION IN PHARMACOLOGY (2016)

Article Endocrinology & Metabolism

Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function

Jeremie Boucher et al.

DIABETES (2016)

Article Endocrinology & Metabolism

Body Mass Index and Risk of Nonalcoholic Fatty Liver Disease: Two Electronic Health Record Prospective Studies

A. Katrina Loomis et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)

Article Medicine, General & Internal

Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids

U. Smith et al.

JOURNAL OF INTERNAL MEDICINE (2016)

Review Behavioral Sciences

The neurobiological basis of binge-eating disorder

Robert M. Kessler et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2016)

Review Nutrition & Dietetics

Circadian regulation of lipid metabolism

Joshua J. Gooley

PROCEEDINGS OF THE NUTRITION SOCIETY (2016)

Article Medicine, General & Internal

Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73)

Christopher E. Ramsden et al.

BMJ-BRITISH MEDICAL JOURNAL (2016)

Article Medicine, General & Internal

Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73)

Christopher E. Ramsden et al.

BMJ-BRITISH MEDICAL JOURNAL (2016)

Article Endocrinology & Metabolism

EBF2 promotes the recruitment of beige adipocytes in white adipose tissue

Rachel R. Stine et al.

MOLECULAR METABOLISM (2016)

Review Biochemistry & Molecular Biology

Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules

Dorothy Moseti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Review Cardiac & Cardiovascular Systems

The Global Burden of Disease Study and the Preventable Burden of NCD

Catherine P. Benziger et al.

GLOBAL HEART (2016)

Review Biochemistry & Molecular Biology

Network of hypothalamic neurons that control appetite

Jong-Woo Sohn

BMB REPORTS (2015)

Review Biochemistry & Molecular Biology

Immune Regulation of Metabolic Homeostasis in Health and Disease

Jonathan R. Brestoff et al.

Review Gastroenterology & Hepatology

The gut microbiome in health and in disease

Andrew B. Shreiner et al.

CURRENT OPINION IN GASTROENTEROLOGY (2015)

Article Medicine, Research & Experimental

Dexamethasone and rosiglitazone are sufficient and necessary for producing functional adipocytes from mesenchymal stem cells

David Contador et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2015)

Article Endocrinology & Metabolism

Phenotypic Characterization of Insulin-Resistant and Insulin-Sensitive Obesity

D. L. Chen et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

Review Medicine, Research & Experimental

Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis

Labros Sidossis et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Review Endocrinology & Metabolism

Metabolic vs. hedonic obesity: a conceptual distinction and its clinical implications

Y-H. Yu et al.

OBESITY REVIEWS (2015)

Review Physiology

OBESITY AND DIABETES: THE INCREASED RISK OF CANCER AND CANCER-RELATED MORTALITY

Emily Jane Gallagher et al.

PHYSIOLOGICAL REVIEWS (2015)

Review Virology

Adenovirus 36 and Obesity: An Overview

Eleonora Ponterio et al.

VIRUSES-BASEL (2015)

Review Chemistry, Multidisciplinary

Farnesoid X receptor: a master regulator of hepatic triglyceride and glucose homeostasis

Yang Jiao et al.

ACTA PHARMACOLOGICA SINICA (2015)

Article Nutrition & Dietetics

Associations of maternal BMI and gestational weight gain with neonatal adiposity in the Healthy Start study

Anne P. Starling et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2015)

Review Economics

The Epidemiology of Obesity: A Big Picture

Adela Hruby et al.

PHARMACOECONOMICS (2015)

Article Endocrinology & Metabolism

Overweight and Obesity: Prevalence, Consequences, and Causes of a Growing Public Health Problem

Ellen P. Williams et al.

CURRENT OBESITY REPORTS (2015)

Article Endocrinology & Metabolism

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

Andre Kleinridders et al.

DIABETES (2014)

Review Gastroenterology & Hepatology

Nonalcoholic Fatty Liver Disease, Hepatic Insulin Resistance, and Type 2 Diabetes

Andreas L. Birkenfeld et al.

HEPATOLOGY (2014)

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Sexual Dimorphisms in the Associations of BMI and Body Fat with Indices of Pubertal Development in Girls and Boys

Melissa K. Crocker et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)

Review Biochemistry & Molecular Biology

Understanding androgen action in adipose tissue

Michael W. O'Reilly et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2014)

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Article Cell Biology

ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes

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SCIENCE TRANSLATIONAL MEDICINE (2014)

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ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2013)

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FXR activation normalizes insulin sensitivity in visceral preadipocytes of a rabbit model of MetS

Elena Maneschi et al.

JOURNAL OF ENDOCRINOLOGY (2013)

Article Biochemistry & Molecular Biology

LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice

Amena Archer et al.

JOURNAL OF LIPID RESEARCH (2013)

Article Physics, Atomic, Molecular & Chemical

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Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

Vanessa K. Ridaura et al.

SCIENCE (2013)

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Androgens inhibit adipogenesis during human adipose stem cell commitment to preadipocyte formation

Gregorio Chazenbalk et al.

STEROIDS (2013)

Review Biochemistry & Molecular Biology

Chronic adipose tissue inflammation: all immune cells on the stage

Goekhan Cildir et al.

TRENDS IN MOLECULAR MEDICINE (2013)

Review Neurosciences

Dopamine signalling in reward-related behaviours

Ja-Hyun Baik

FRONTIERS IN NEURAL CIRCUITS (2013)

Article Endocrinology & Metabolism

Thyroid Hormones and the Metabolic Syndrome

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EUROPEAN THYROID JOURNAL (2013)

Article Obstetrics & Gynecology

Understanding weight gain at menopause

S. R. Davis et al.

CLIMACTERIC (2012)

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Metabolic Programming, Epigenetics, and Gestational Diabetes Mellitus

Sara E. Pinney et al.

CURRENT DIABETES REPORTS (2012)

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