4.7 Article

Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Cell Senescence, DNA Damage, and Metabolism

Riva Shmulevich et al.

Summary: Senescence is a crucial biological process that can block tumorigenesis and limit tissue damage, but accumulation of senescent cells can promote age-related diseases. Recent advances have shown the significant role of cellular metabolism in regulating cell senescence, and future research should focus on elucidating metabolic mechanisms to develop new therapeutic strategies.

ANTIOXIDANTS & REDOX SIGNALING (2021)

Review Rheumatology

Mechanisms and therapeutic implications of cellular senescence in osteoarthritis

Philip R. Coryell et al.

Summary: The development of osteoarthritis (OA) is correlated with an increase in senescent cells in joint tissues, with senescence-associated secretory phenotype (SASP) implicated in cartilage degradation and OA. Developing therapeutics like senolytics or senomorphics to eliminate or alter senescent cells may halt the progression and pathogenesis of OA.

NATURE REVIEWS RHEUMATOLOGY (2021)

Article Cell Biology

STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway

Qiang Guo et al.

Summary: The study investigated the role of STING in osteoarthritis progression, revealing its involvement in ECM metabolism, apoptosis, and senescence in chondrocytes. STING activation of NF-kappa B signaling cascade was found to contribute to OA development, with suppression of STING showing potential as a therapeutic approach.

CELL DEATH & DISEASE (2021)

Review Neurosciences

Signaling by cGAS-STING in Neurodegeneration, Neuroinflammation, and Aging

Bindu D. Paul et al.

Summary: Recognition of foreign or misplaced nucleic acids is crucial for immune system to detect pathogens. The cGAS-STING pathway plays a key role in this process, but excessive engagement may lead to neuroinflammation and disease progression.

TRENDS IN NEUROSCIENCES (2021)

Review Orthopedics

The role of macrophages in osteoarthritis and cartilage repair

C-L Wu et al.

OSTEOARTHRITIS AND CARTILAGE (2020)

Review Immunology

Macrophage: A Potential Target on Cartilage Regeneration

Tiago Lazzaretti Fernandes et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Cell Biology

Molecular mechanisms and cellular functions of cGAS-STING signalling

Karl-Peter Hopfner et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

DNA Damage and Cancer Immunotherapy: A STING in the Tale

Timo Reislander et al.

MOLECULAR CELL (2020)

Review Biochemistry & Molecular Biology

Redox and NF-κB signaling in osteoarthritis

Panagiotis Lepetsos et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Orthopedics

OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis

R. R. Bannuru et al.

OSTEOARTHRITIS AND CARTILAGE (2019)

Article Biochemistry & Molecular Biology

Octyl itaconate inhibits osteoclastogenesis by suppressing Hrd1 and activating Nrf2 signaling

Xuewu Sun et al.

FASEB JOURNAL (2019)

Review Immunology

The Immunomodulatory Potential of the Metabolite Itaconate

Alexander Hooftman et al.

TRENDS IN IMMUNOLOGY (2019)

Review Immunology

Itaconate: the poster child of metabolic reprogramming in macrophage function

Luke A. J. O'Neill et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Review Cell Biology

Macrophage plasticity, polarization, and function in health and disease

Abbas Shapouri-Moghaddam et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Review Immunology

The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer

Tuo Li et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

Article Multidisciplinary Sciences

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills et al.

NATURE (2018)

Article Multidisciplinary Sciences

Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation

Yujie Deng et al.

NATURE COMMUNICATIONS (2018)

Editorial Material Cell Biology

DNA damage-induced immune response: Micronuclei provide key platform

Nelson O. Gekara

JOURNAL OF CELL BIOLOGY (2017)

Review Rheumatology

Ageing and the pathogenesis of osteoarthritis

Richard F. Loeser et al.

NATURE REVIEWS RHEUMATOLOGY (2016)

Review Pharmacology & Pharmacy

Antidepressant therapies inhibit inflammation and microglial M1-polarization

Hans O. Kalkman et al.

PHARMACOLOGY & THERAPEUTICS (2016)

Article Orthopedics

Inflammation and intracellular metabolism: new targets in OA

R. Liu-Bryan

OSTEOARTHRITIS AND CARTILAGE (2015)

Review Biotechnology & Applied Microbiology

Future nanomedicine for the diagnosis and treatment of osteoarthritis

Lauren R. Eichaker et al.

NANOMEDICINE (2014)

Article Multidisciplinary Sciences

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

Jan Petrasek et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Endocrinology & Metabolism

The role of synovitis in osteoarthritis pathogenesis

Carla R. Scanzello et al.

Article Immunology

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

Christian K. Holm et al.

NATURE IMMUNOLOGY (2012)

Review Rheumatology

Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis

Paul I. Mapp et al.

NATURE REVIEWS RHEUMATOLOGY (2012)

Review Orthopedics

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

B. J. E. de Lange-Brokaar et al.

OSTEOARTHRITIS AND CARTILAGE (2012)

Article Rheumatology

Synovial tissue inflammation in early and late osteoarthritis

MJ Benito et al.

ANNALS OF THE RHEUMATIC DISEASES (2005)

Review Immunology

The chemokine system in diverse forms of macrophage activation and polarization

A Mantovani et al.

TRENDS IN IMMUNOLOGY (2004)