期刊
BIOCHEMICAL PHARMACOLOGY
卷 200, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2022.115033
关键词
Methionine Cycle; NAFLD
资金
- Shanghai Committee of Science and Technology, China [20ZR1468300]
- State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences [SIMM2004KF-15]
This article focuses on the pathogenesis and therapeutic strategies of Nonalcoholic Fatty Liver Disease (NAFLD), specifically exploring the interconnections between specific enzymes involved in the methionine metabolic cycle and NAFLD.
As a chronic metabolic disease affecting epidemic proportions worldwide, the pathogenesis of Nonalcoholic Fatty Liver Disease (NAFLD) is not clear yet. There is also a lack of precise biomarkers and specific medicine for the diagnosis and treatment of NAFLD. Methionine metabolic cycle, which is critical for the maintaining of cellular methylation and redox state, is involved in the pathophysiology of NAFLD. However, the molecular basis and mechanism of methionine metabolism in NAFLD are not completely understood. Here, we mainly focus on specific enzymes that participates in methionine cycle, to reveal their interconnections with NAFLD, in order to recognize the pathogenesis of NAFLD from a new angle and at the same time, explore the clinical characteristics and therapeutic strategies.
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